PMID: 8945515Nov 29, 1996Paper

Helicase-contrahelicase interaction and the mechanism of termination of DNA replication

Cell
A C MannaD Bastia

Abstract

Termination of DNA replication at a sequence-specific replication terminus is potentiated by the binding of the replication terminator protein (RTP) to the terminus sequence, causing polar arrest of the replicative helicase (contrahelicase activity). Two alternative models have been proposed to explain the mechanism of replication fork arrest. In the first model, the RTP-terminus DNA interaction simply imposes a polar barrier to helicase movement without involving any specific interaction between the helicase and the terminator proteins. The second model proposes that there is a specific interaction between the two proteins, and that the DNA-protein interaction both restricts the fork arrest to the replication terminus and determines the polarity of the process. The evidence presented in this paper strongly supports the second model.

References

Oct 5, 1992·Journal of Molecular Biology·M T Smith, R G Wake
Sep 1, 1991·Research in Microbiology·P J Lewis, R G Wake
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E H LeeT Horiuchi
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M S Lee, K J Marians
Nov 1, 1988·Molecular and Cellular Biology·M H Linskens, J A Huberman
May 1, 1995·Journal of Structural Biology·M C San MartinJ M Carazo
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·E H EgelmanS S Patel
Aug 19, 1994·Journal of Molecular Biology·M T SmithR G Wake
Oct 1, 1993·Molecular and Cellular Biology·R D LittleC L Schildkraut
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·A C MannaD Bastia
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·P V RatnakarD Bastia
May 31, 1996·Journal of Molecular Biology·X YuE H Egelman
Jul 5, 1996·Journal of Molecular Biology·M T SmithR G Wake
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K S PaiD Bastia
Nov 28, 1996·Nature·S C West
Apr 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·H YOSHIKAWA, N SUEOKA
Jun 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·H YOSHIKAWA, N SUEOKA
Jan 23, 1987·Science·A T BrüngerM Karplus

❮ Previous
Next ❯

Citations

Nov 25, 2003·Nucleic Acids Research·Rajesh K SoniSuman Kumar Dhar
Aug 31, 2006·Molecular and Cellular Biology·Gregor Krings, Deepak Bastia
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Cameron NeylonNicholas E Dixon
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·S MuluguD Bastia
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bidyut K MohantyDeepak Bastia
Sep 2, 2009·Protein Science : a Publication of the Protein Society·Bulat I KhayrutdinovYunje Cho
Nov 21, 2008·Molecular Microbiology·Iain G DugginThomas M Hill
Mar 6, 2013·Journal of Molecular Biology·Charanya KumarJennifer A Surtees
May 9, 2014·Seminars in Cell & Developmental Biology·Deepak Bastia, Shamsu Zaman
Oct 1, 2005·The Journal of Biological Chemistry·Gregor Krings, Deepak Bastia
Apr 21, 1999·Molecular Microbiology·D E Bussiere, D Bastia
Mar 6, 1999·The Journal of Biological Chemistry·D L Kaplan, T A Steitz
Mar 13, 2001·Journal of Molecular Biology·D SikderV Nagaraja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.