Helicobacter pylori and gastric acid: biological and therapeutic implications

Gastroenterology
C C McGowanM J Blaser

Abstract

Helicobacter pylori is highly adapted to its unusual ecological niche in the human stomach. Urease activity permits H. pylori survival at a pH of <4 in vitro and is required for the organism to colonize in animal models. However, urease does not play an important role in the survival of the organism in a pH range between 4 and 7. Other mechanisms of pH homeostasis remain poorly understood, but preliminary studies indicate that novel proteins are produced when H.pylori cells are shifted from pH 7 to 3, and the gene encoding a P-type adenosine triphosphatase that may catalyze NH4+/H+ exchange across the cytoplasmic membrane has been cloned. Mechanisms of pH homeostasis in other enteric bacteria are reviewed and provide insight into additional pathways that may be used by H. pylori. An important adaptation of H. pylori to the gastric environment may be its ability to alter gastric acid secretion. Acute infection is associated with transient hypochlorhydria, whereas chronic infection is associated with hypergastrinemia and decreased somatostatin levels. Thus, the survival of H. pylori in the gastric environment may be attributed to both the development of specialized intrinsic defenses and the organism's ability to induce physiolog...Continue Reading

Citations

Apr 3, 2013·Thyroid : Official Journal of the American Thyroid Association·Wei-Jia ShiGuo-Xin Zhang
Feb 3, 1999·Annals of the New York Academy of Sciences·M M Walker, J E Crabtree
Jul 23, 1999·Annals of the New York Academy of Sciences·G J MolderingsM Göthert
Feb 13, 2001·Infection and Immunity·K StinglK Altendorf
Apr 20, 2006·Infection and Immunity·John T Loh, Timothy L Cover
Jul 14, 2000·Journal of Bacteriology·G HomuthW Schumann
Jul 14, 1999·Gut·H B El-SeragR M Feddersen
Jan 1, 1997·Annual Review of Physiology·M Sawada, C J Dickinson
Mar 8, 2013·World Journal of Gastroenterology : WJG·Saurabh Kumar PatelGopal Nath
Jan 1, 1997·Scandinavian Journal of Gastroenterology·G OberhuberM Stolte
Feb 1, 1997·The American Journal of Medicine·R M Peek, M J Blaser
Feb 25, 2015·Medical Molecular Morphology·Hong WuKouichi Sano
Sep 8, 2015·Current Treatment Options in Gastroenterology·Jennifer PhanJoseph R Pisegna
Jun 6, 2003·Molecular Microbiology·Catherine C McGowanMartin J Blaser
Nov 3, 2007·Evolution; International Journal of Organic Evolution·David A BaltrusPatrick C Phillips
Nov 9, 2005·Bioorganic & Medicinal Chemistry Letters·Ghilsoo NamKyung Il Choi
Jan 15, 1998·Gastroenterology·D R ScottG Sachs
Jul 24, 2002·Gastroenterology Clinics of North America·Hashem B el-Serag
Jul 18, 1997·Biochemical and Biophysical Research Communications·C OotsuboY Kohgo
Dec 31, 2014·BioMed Research International·Meng-Chieh WuChien-Yu Lu
Apr 15, 1999·The Veterinary Clinics of North America. Small Animal Practice·D Strauss-Ayali, K W Simpson
Jul 26, 2016·Frontiers in Pharmacology·Muhammad U AshrafSyed N A Bukhari
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·D K ManifoldW J Owen
Dec 31, 2014·PloS One·Swati SinghLalitha Guruprasad
Jul 11, 2013·PloS One·Timothy T PerkinsBarry Marshall

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