PMID: 11321384Apr 26, 2001Paper

Helicobacter pylori and Meckel's diverticula

Journal of Pediatric Gastroenterology and Nutrition
L S Finn, D L Christie

Abstract

Helicobacter pylori is known to infect only gastric mucosa and is strongly associated with gastroduodenal ulceration. The authors studied whether H. pylori colonizes the gastric mucosa of Meckel's diverticula, and determined its relationship to "gastritis" and bleeding. A 10-year retrospective review identified 45 children with Meckel's diverticulum. Hematoxylin-eosin and Diff-Quik stains were used to assess the presence and severity of gastritis, and to highlight organisms in the resected diverticula. Cases with organisms were then studied with antibodies specific for H. pylori using immunoperoxidase methods. Twenty-eight children, 7 months to 12.6 years of age, had lower gastrointestinal hemorrhage caused by Meckel's diverticulum and had positive radionuclide scans. All had acid-secreting mucosa in their diverticula, and ulceration. "Chronic gastritis" and eosinophilia were constant findings; "acute gastritis" was present in four patients. Twenty specimens exhibited lymphoid follicles in the gastric mucosa. Seventeen patients with Meckel's diverticula (age range, 1 month-14.7 years) who presented with acute abdominal pain associated with intussusception were used for comparison. Acid-secreting gastric mucosa was seen in four ...Continue Reading

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Citations

Oct 13, 2007·Journal of Gastroenterology and Hepatology·Satoshi ShinozakiKentaro Sugano
Oct 9, 2003·Journal of Clinical Microbiology·W G MacKayL T Weaver
Aug 30, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Snezana PavlovićVladimir Zivković
Nov 1, 2011·World Journal of Gastroenterology : WJG·Peren H KaraginAsa Ljungh
Aug 29, 2009·Digestive Diseases and Sciences·Ahmet TuzunAhmet Uygun
May 21, 2019·Clinical Medicine Insights. Case Reports·Thomas Surya SuhardjaZoltan Hrabovszky

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