PMID: 9445181Jan 28, 1998Paper

Helicobacter pylori and the null genotype of glutathione-S-transferase-mu in patients with gastric adenocarcinoma

Cancer
E K NgS C Chung

Abstract

Chronic Helicobacter pylori infection now is recognized as an important causative agent for gastric carcinoma. However, only a small minority of infected individuals develop the malignancy, even in areas with a high prevalence of gastric carcinoma. It has been postulated that the absence of glutathione-S-transferase-mu (GST-mu), which impairs detoxification of exogenous carcinogens, might predispose some infected individuals to the development of gastric carcinoma. Patients with histologically confirmed adenocarcinoma of the stomach were tested for H. pylori infection and the GST-mu genotype. Prevalence of GST-mu gene deletion was compared with the H. pylori status of the patients. A group of gender- and age-matched control subjects with known H. pylori-related nonulcer dyspepsia also were tested for the GST-mu genotype and compared with patients with H. pylori positive carcinoma. Fifty-one patients with gastric adenocarcinoma were enrolled into the study. Thirty-five were found to have H. pylori in the resected specimens. The null genotype of GST-mu was significantly more common among those patients with H. pylori positive carcinoma compared with the H. pylori negative group (65.7% vs. 31.3%; P < 0.05). Homozygous deletion of ...Continue Reading

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Citations

Jun 21, 2014·Diagnostic Pathology·Xianhong MengBona Liu
Oct 9, 2004·Cell Biochemistry and Function·Lülüfer TamerSüha Aydin
Mar 23, 2017·Arquivos De Gastroenterologia·Rívian Xavier RibeiroAntonio Márcio Teodoro Cordeiro Silva
May 10, 2011·Molecular Biology Reports·Yu ZhuHai-Feng Pan
Apr 28, 2004·World Journal of Gastroenterology : WJG·Jucimara ColomboAna Elizabete Silva

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