Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates

PloS One
Aeryun KimJeong-Heon Cha

Abstract

Helicobacter pylori genetic variation is a crucial component of colonization and persistence within the inhospitable niche of the gastric mucosa. As such, numerous H. pylori genes have been shown to vary in terms of presence and genomic location within this pathogen. Among the variable factors, the Bab family of outer membrane proteins (OMPs) has been shown to differ within subsets of strains. To better understand genetic variation among the bab genes and to determine whether this variation differed among isolates obtained from different geographic locations, we characterized the distribution of the Bab family members in 80 American H. pylori clinical isolates (AH) and 80 South Korean H. pylori clinical isolates (KH). Overall, we identified 23 different bab genotypes (19 in AH and 11 in KH), but only 5 occurred in greater than 5 isolates. Regardless of strain origin, a strain in which locus A and locus B were both occupied by a bab gene was the most common (85%); locus C was only occupied in those isolates that carried bab paralog at locus A and B. While the babA/babB/- genotype predominated in the KH (78.8%), no single genotype could account for greater than 40% in the AH collection. In addition to basic genotyping, we also id...Continue Reading

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Citations

Jul 12, 2017·World Journal of Gastroenterology : WJG·Shamshul Ansari, Yoshio Yamaoka
Aug 9, 2017·World Journal of Gastroenterology : WJG·Vasiliy Ivanovich Reshetnyak, Tatiana Magomedalievna Reshetnyak
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Aug 18, 2018·Frontiers in Microbiology·Stephanie L ServetasD Scott Merrell
Nov 11, 2021·The Journal of Microbiology·Kavinda TisseraJeong-Heon Cha

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Datasets Mentioned

BETA
KP339308
KP339491

Methods Mentioned

BETA
biopsies
genotyping
PCRs
PCR

Software Mentioned

CONSENSE
PHYLIP
PARS
Phylogeny Inference Package
SPSS
SEQBOOT
SAS

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