Abstract
Beyond peptic ulcer disease, Helicobacter pylori infection is associated with intestinal-type gastric cancer and low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is also currently implicated as a possible cause of dyspepsia and extraintestinal disorders such as coronary artery disease, rosacea, chronic urticaria, and delayed growth in children. There are strong epidemiological data from large cohort studies linking H. pylori to gastric adenocarcinoma. Several cofactors, including early childhood acquisition of infection, strain-specific differences, genetic predisposition of the host, and the environment, appear to play a role in the progression of chronic gastritis to gastric cancer. H. pylori infection is seen in over 90% of MALT lymphomas, and about 70% of localized nonbulky tumors will undergo complete histological regression after eradication of the bacterium. Because follow-up data are limited to less than 2 years, those undergoing H. pylori eradication as primary therapy for MALT lymphoma require frequent histological surveillance for tumor recurrence. There are conflicting data from short-term studies regarding the effect of H. pylori eradication on dyspeptic symptoms. The decision to test or not ...Continue Reading
References
Oct 1, 1975·Pathology·D I Annear
Aug 10, 1991·Lancet·J E CrabtreeB J Rathbone
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Aug 1, 1987·Journal of Clinical Pathology·J I WyattR V Heatley
Oct 1, 1986·Gut·A Sonnenberg
Jul 4, 1970·Lancet·D I Annear
Apr 21, 1972·Nature·J W BlackE M Parsons
Jun 16, 1984·Lancet·B J Marshall, J R Warren
Dec 1, 1980·Clinical Science·N L JonesC J Toews
Aug 5, 1995·Lancet·I L BealesJ Calam
Feb 26, 1994·Lancet·T AzumaY Kohli
Feb 7, 1994·NIH Consensus Statement
Jul 6, 1994·JAMA : the Journal of the American Medical Association
Jun 1, 1994·Gut·J C Atherton, R C Spiller
Jun 15, 1994·Annals of Internal Medicine·H M MalatyD Y Graham
Jul 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T U WestblomS J Czinn
Jul 1, 1993·The Journal of Infectious Diseases·N BanatvalaR A Feldman
Sep 1, 1995·Baillière's Clinical Gastroenterology·A W Harris, J J Misiewicz
Jul 25, 1996·The New England Journal of Medicine·L E HanssonH O Adami
Jun 1, 1994·Environmental Health Perspectives·H VainioJ Wilbourn
Citations
Feb 22, 2000·Clinical Cornerstone·A H Soll
Mar 13, 1999·Seminars in Oncology Nursing·K G O'Connor
Feb 11, 2016·World Journal of Clinical Oncology·Clarke Brian Blackadar
Jul 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohanraj RamachandranMagnus Essand