Helicobacter pylori-CagA seropositivity and nitrite and ascorbic acid food intake as predictors for gastric cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Lizbeth López-CarrilloMalaquías López-Cervantes

Abstract

A hospital-based case-control study was carried out between 1994 and 1996 to evaluate the risk of gastric cancer (GC) according to Helicobacter pylori-CagA (+) seropositivity, nitrite and ascorbic acid intake. Three geographical areas of Mexico were selected on the basis of their contrasting dietary patterns and H. pylori seroprevalence. Nitrite and ascorbic acid consumption were estimated by interview among 211 cases and 454 matched controls. Serum antibodies against IgG H. pylori and CagA were detected by immunosorbent assays. The adjusted risk for GC was significantly higher among CagA+ subjects compared with those that were CagA negative (Odds Ratio (OR)=2.04 95% Confidence Interval (CI) 1.37-3.02 P for trend P < 0.001), this effect remained significant among diffuse GC cases (OR 2.05 95% CI 1.25-3-36). No significant effects due to nitrite and ascorbic consumption or interactions of these nutrients with CagA seropositivity were detected. Seropositivity to H. pylori CagA+ strains may be an independent factor for diffuse GC in Mexico.

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Citations

Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nuno LunetHenrique Barros
Apr 7, 2005·Digestive Diseases·Rocco Maurizio Zagari, Franco Bazzoli
May 17, 2011·Annals of Clinical Microbiology and Antimicrobials·Fernando Antonio-RincónGermán R Aguilar-Gutiérrez
May 2, 2014·World Journal of Gastroenterology : WJG·Clara Luz Sampieri, Mauricio Mora
Dec 25, 2009·Scandinavian Journal of Gastroenterology·Carlos A González, Lizbeth López-Carrillo
Aug 23, 2005·International Journal of Cancer. Journal International Du Cancer·Liviu A SicinschiBarbara G Schneider
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Peiwei LiYihua Wu
Jun 30, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Judit Alarcón-MillánAdolfo Román-Román
Sep 13, 2006·Nutrition and Cancer·Nuno LunetHenrique Barros
Jul 7, 2007·Scandinavian Journal of Gastroenterology·J Henrik SimánClaes-Henrik Florén
Feb 27, 2019·Environmental Science and Pollution Research International·Hamid Reza GhaffariAhad Eshraghian
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezElio Riboli

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