Helicobacter pylori colonization of the human gastric epithelium: a bug's first step is a novel target for us

Journal of Gastroenterology and Hepatology
Bor-Shyang SheuJiunn-Jong Wu

Abstract

After Helicobacter pylori enters the stomach, three steps are vital for infection: (i) establishing colonization; (ii) evading host immunity; and (iii) invading gastric mucosa; the last step is what is associated with diverse outcomes. Urease activity and motility mediated by the flagella of H. pylori are important in harboring colonies beneath the gastric mucus in niches adjacent to the epithelium. Several putative adhesins attach the organism to the gastric epithelium and prompt the succeeding processes for evading host immunity and invading the mucosa. Successful colonization is thus the leading and critical step. From another point of view, this can be a novel target to control this common and important infection. This review summarizes the putative adhesins that influence the evasion of host immunity, and how these could determine different clinico-pathologic outcomes. The putative adhesins include the interplay between bacterial and host Lewis antigens (type I: Le(a) and Le(b); type II: Le(x) and Le(y)), the dominant pathway between BabA and Le(b), the SabA adhesin binding to sialylated Le(x) that is upregulated in inflamed gastric tissue or those with weak-Le(b), the CagL apparatus to adapt with the alpha5beta1 integrin ...Continue Reading

References

Apr 1, 1992·Infection and Immunity·A MuotialaA P Moran
Apr 1, 1992·Journal of Clinical Pathology·K Kobashi
Aug 1, 1992·Journal of Medical Microbiology·K A EatonS Krakowka
Oct 1, 1993·Physiological Reviews·A AllenE Kivilaakso
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Oct 10, 1997·Gastroenterology·H P WirthM J Blaser
Dec 12, 1997·Gastroenterology·H L Mobley
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M GerhardC Prinz
Apr 15, 2000·Gut·G R Van den BrinkJ Dekker
Aug 10, 2000·Molecular Microbiology·G WangD E Taylor
Feb 13, 2001·Infection and Immunity·D T PrideM J Blaser
Jun 14, 2002·FEBS Letters·Yoshio YamaokaDavid Y Graham
Aug 9, 2003·Journal of Clinical Microbiology·Adriana Gonçalves OliveiraDulciene Maria Magalhães Queiroz
Oct 11, 2003·Helicobacter·Jeroen H B Van de BovenkampJan Dekker
Oct 22, 2003·Lancet·Michael Höcker, Peter Hohenberger
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sören SchreiberSebastian Suerbaum
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali A AkhianiNils Lycke
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anna BäckströmAnna Arnqvist
Dec 3, 2004·Digestive Diseases and Sciences·Samuel B HoHiroyoshi Ota

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Citations

Jul 19, 2013·World Journal of Gastroenterology : WJG·Mo-Ye ChenYuan Yuan
Feb 21, 2014·BMC Gastroenterology·Amin Talebi Bezmin AbadiJohannes G Kusters
Nov 5, 2015·Pathogens and Disease·Francesca RosadiAlessia Fabbri
Aug 25, 2015·Journal of Ethnopharmacology·Jazmín Espinosa-RiveroIrma Romero
Jan 1, 2013·Biology·Johanna Haiko, Benita Westerlund-Wikström
Jul 24, 2018·Journal of Medicinal Food·Erika Gomez-ChangIrma Romero
Oct 4, 2014·World Journal of Gastroenterology : WJG·Mislav Radić
Jun 20, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Chenjing XuShunfu Xu
Sep 25, 2010·Biochemical Society Transactions·Jared Q GerlachLokesh Joshi
Sep 13, 2018·Journal of Biomedical Science·Wei-Lun ChangBor-Shyang Sheu
Mar 14, 2020·International Journal of Molecular Sciences·Sandra Salillas, Javier Sancho
Dec 17, 2020·Journal of Clinical Medicine·Ana-Maria Teodora DomșaCristina Maria Borzan
Feb 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Manouchehr Ahmadi Hedayati, Saeed Salavati
Jul 25, 2021·International Journal of Molecular Sciences·Marko NedeljkovićEric John Sundberg

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