Helicobacter pylori density and cagA status in cirrhotic patients: a case-control study

Journal of Gastroenterology and Hepatology
Angelo ZulloSergio Morini

Abstract

Despite a similar Helicobacter pylori prevalence, peptic ulcer is more frequent in cirrhotic patients than in controls. We evaluated whether cirrhotic patients had an increased bacterial density and/or a higher prevalence of H. pylori cagA-positive strains than controls. A total of 36 dyspeptic cirrhotic patients with H. pylori infection and 72 matched controls were enrolled. H. pylori infection was detected at histology on Giemsa staining, bacterial density was assessed using difference over baseline (DOB) values at 13C urea breath test, and cagA status was established at serology. Overall, both DOB values and prevalence of cagA did not significantly differ between cirrhotic patients and controls. However, peptic ulcer controls showed significantly higher DOB value (27.9 +/- 17.4 vs 19.4 +/- 9.3, respectively; P = 0.009) and cagA positive rate (85%vs 48%; P = 0.01) than non-ulcer dyspepsia patients. Although not statistically significant, a similar trend was observed in cirrhotic patients with peptic ulcer for DOB values (26.5 +/- 16.3 vs 18.3/1000 +/- 9.2, respectively; P = 0.07), whereas the cagA-positive rate was similar between peptic ulcer and non-ulcer dyspepsia patients (60%vs 50%; P = 0.30). The present data showed tha...Continue Reading

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Citations

Mar 20, 2008·World Journal of Gastroenterology : WJG·Shu-Jie ChenJian-Min Si
Jun 29, 2007·Digestive Diseases and Sciences·Angelo ZulloDino Vaira
Apr 23, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Sreenivasulu PuramVenkateswarlu Kudiganti
Jun 21, 2012·Journal of Digestive Diseases·Huck-Joo Tan, Khean-Lee Goh
Jan 23, 2010·Journal of Medical Microbiology·Vincenzo De FrancescoEnzo Ierardi

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