PMID: 8971303Dec 1, 1996Paper

Helicobacter pylori eradication in clinical practice: one-week low-dose triple therapy is preferable to classical bismuth based triple therapy

Alimentary Pharmacology & Therapeutics
A F Goddard, R C Spiller

Abstract

Both classical 2-week bismuth based triple therapy and the newer 1-week low-dose omeprazole based triple therapies achieve high Helicobacter pylori eradication rates in controlled clinical trials and are in widespread use in routine clinical practice. However, their efficacy and acceptability in this setting is unproved. Over a 1-year period, the notes for patients attending a dedicated H. pylori treatment clinic were audited. Assessments were made of patient demographics, diagnosis, smoking habits, use of H2-antagonists, regimen used, efficacy of treatment, compliance and side-effects experienced. 223 sets of notes were audited. 89 patients received bismuth, tetracycline and metronidazole for two weeks and 111 patients received omeprazole, clarithromycin and either metronidazole (63 patients) or tinidazole (48 patients) for 1 week. Successful eradication was achieved in 75/89 (84.3%), 56/63 (89%) and 42/48 (88%), respectively, (P = N.S.). Severe side-effects occurred in 11 (12%) of patients receiving bismuth based treatment compared to 1 (0.9%) patient receiving omeprazole based regimens (P < 0.02). Treatment failure in patients receiving omeprazole based treatment was associated with smoking (P < 0.05). Outside the context of...Continue Reading

Citations

Aug 1, 1997·Alimentary Pharmacology & Therapeutics·A F Goddard, R P Logan
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·G A PipkinJ R Wood
Oct 28, 2008·Advances in Medical Sciences·D B NamiotA Kemona
May 17, 2006·Alimentary Pharmacology & Therapeutics·C Scarpignato, I Pelosini
Mar 22, 2014·International Journal of Radiation Biology·Prabath G BijuAlexander F Burnett
Feb 3, 2007·Expert Opinion on Pharmacotherapy·Gerhard TreiberUlrich Klotz
May 5, 2001·Expert Opinion on Pharmacotherapy·H H XiaS K Lam
Nov 19, 2002·Revista do Hospital das Clínicas·Fernando Marcuz SilvaAntonio Atílio Laudanna
Mar 27, 2002·International Journal of Epidemiology·Lori A FischbachCorinne Aragaki
Jun 1, 1997·Alimentary Pharmacology & Therapeutics·M E McAlindonS D Ryder
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Michele Scaillon, Samy Cadranel
Jun 22, 2000·The Annals of Pharmacotherapy·K A Fairman, B R Motheral
Oct 29, 2021·Helicobacter·Jing YuXiaoyong Wang

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