Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography

Helicobacter
Galit H FrydmanJames G Fox

Abstract

Idiopathic thrombocytopenic purpura (ITP) is typically a diagnosis of exclusion, assigned by clinicians after ruling out other identifiable etiologies. Since a report by Gasbarrini et al. in 1998, an accumulating body of evidence has proposed a pathophysiological link between ITP and chronic Helicobacter pylori (H. pylori) infection. Clinical reports have described a spontaneous resolution of ITP symptoms in about 50% of chronic ITP patients following empirical treatment of H. pylori infection, but response appears to be geography dependent. Studies have also documented that ITP patients in East Asian countries are more likely to express positive antibody titers against H. pylori-specific cytotoxic-associated gene A (CagA), a virulence factor that is associated with an increased risk for gastric diseases including carcinoma. While a definitive mechanism by which H. pylori may induce thrombocytopenia remains elusive, proposed pathways include molecular mimicry of CagA by host autoantibodies against platelet surface glycoproteins, as well as perturbations in the phagocytic activity of monocytes. Traditional treatments of ITP have been largely empirical, involving the use of immunosuppressive agents and immunoglobulin therapy. How...Continue Reading

References

Jan 1, 1977·Seminars in Thrombosis and Hemostasis·C Mueller-Eckhardt
Dec 6, 1995·Journal of the National Cancer Institute·E J KuipersM J Blaser
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·E D SegalL S Tompkins
Jul 31, 1998·Immunogenetics·W van der Pol, J G van de Winkel
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·E D SegalL S Tompkins
Dec 22, 1999·JAMA : the Journal of the American Medical Association·J ParsonnetT Haggerty
Aug 31, 2000·Zeitschrift für Gastroenterologie·J RudiW Stremmel
Jan 15, 2002·The Journal of Biological Chemistry·Matthias SelbachSteffen Backert
Jun 14, 2002·FEBS Letters·Yoshio YamaokaDavid Y Graham
Aug 30, 2002·British Journal of Haematology·Drew Provan, Adrian Newland
Sep 19, 2002·The Pediatric Infectious Disease Journal·Dietrich RothenbacherHermann Brenner
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hideaki HigashiMasanori Hatakeyama
Feb 18, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology General Haematology Task Force
Jun 20, 2003·Microbes and Infection·Robert W Frenck, John Clemens
Aug 7, 2003·Journal of Pediatric Hematology/oncology·Linda J Butros, James B Bussel
Feb 14, 2004·The Journal of Biological Chemistry·Hideaki HigashiMasanori Hatakeyama
May 6, 2004·Annals of Internal Medicine·Francesco FranceschiRobert M Genta
Jul 24, 2004·Helicobacter·Massimo Franchini, Dino Veneri
Sep 3, 2004·Nature Reviews. Cancer·Masanori Hatakeyama
Mar 9, 2005·Current Biology : CB·Franck PrugnolleFrançois Balloux
Apr 6, 2005·The American Journal of Medicine·Roberto StasiDrew Provan
Apr 6, 2005·The American Journal of Medicine·Giovanni EmiliaGiuseppe Torelli

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Citations

Feb 27, 2019·Journal of Veterinary Internal Medicine·Oliver A GardenBalazs Szladovits
Sep 21, 2019·Veterinary Clinical Pathology·Dana N LeVine, Marjory B Brooks
Apr 6, 2019·European Journal of Gastroenterology & Hepatology·Longui NingGuoqiang Xu
Jun 23, 2020·International Journal of Immunopathology and Pharmacology·Xi XieYuyong Wang
Feb 1, 2019·Terapevticheskiĭ arkhiv·L I Dvoretsky, S V Yakovlev
Aug 29, 2020·Science China. Life Sciences·Yanan WangXiaohui Zhang
Sep 30, 2020·The Journal of Experimental Medicine·Masahiro NagataSho Yamasaki
Apr 19, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJoaquim Prado de Moraes-Filho
Nov 8, 2018·Gastroenterology Research and Practice·Bum Jun KimJung Han Kim
Jul 30, 2020·Mediators of Inflammation·Salah A Sheweita, Awad S Alsamghan
Sep 3, 2020·Medicine·Maria Oana SăsăranEcaterina Daniela Dobru
Jun 4, 2016·The Medical Journal of Australia·Hazel Mitchell, Peter Katelaris
Feb 23, 2019·Journal of Community Hospital Internal Medicine Perspectives·Abir ZainalRichard Alweis
Jul 26, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJosé Vitor Zir
Oct 19, 2020·Journal of Thrombosis and Haemostasis : JTH·Prakash VishnuUNKNOWN Platelet Immunology Scientific, Standardization Committee
Mar 6, 2021·Critical Reviews in Oncology/hematology·Bruno FattizzoWilma Barcellini
Mar 17, 2021·Expert Review of Clinical Pharmacology·Rajeev SandalAhmad Daniyal Siddiqui
Mar 13, 2021·Blood Research·Seyed Mohammad Sadegh PezeshkiArshid Yousefi Avarvand

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