Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

SAGE Open Medicine
Seung-Joo NamJong Kyu Park

Abstract

To compare Helicobacter pylori (H. pylori) eradication rate of type 2 diabetic patients with non-diabetic subjects. In this multicenter prospective observational study, H. pylori-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication. Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011-0.909, p value: 0.041). Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may...Continue Reading

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Citations

Feb 19, 2020·Molecular Genetics & Genomic Medicine·Abolfazl Zendehdel, Maryam Roham

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Methods Mentioned

BETA
biopsy

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