PMID: 16625983Apr 22, 2006Paper

Helicobacter pylori eradication prior to initiation of long-term non-steroidal anti-inflammatory drug therapy in Chinese patients-a cost-effectiveness analysis

International Journal of Clinical Pharmacology and Therapeutics
J H S YouK K C Lee

Abstract

Recent randomized clinical trials suggested that eradication of Helicobacter pylori prior to initiation of non-steroidal anti-inflammatory drug (NSAID) therapy would reduce the rate of peptic ulcer disease (PUD). To analyze the cost-effectiveness of H. pylori eradication prior to initiation of long-term NSAID therapy for prevention of NSAID-induced PUD in a cohort of Chinese patients at high risk for PUD. Clinical and economic data of 100 participants from a previously reported clinical trial conducted in Hong Kong were analyzed. Patients with a history of peptic ulcers were randomized to 1-week omeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg twice daily (eradication group; n = 51) or 1-week omeprazole 20 mg twice daily (omeprazole group; n = 49) before initiation of diclofenac 100 mg daily for 6 months. The rates of PUD and healthcare utilization for routine follow-up as well as for management of symptomatic PUD of the 2 groups were retrieved from medical records. The rate of symptomatic ulcers in eradication group and omeprazole group were 3.9% and 18%, respectively. The mean direct medical cost of the eradication group was significantly lower than that of the omeprazole group by 30% (US dollar 797 (95% CI = 685 -...Continue Reading

Citations

Jul 9, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·J H BijekP Mathevet
Nov 3, 2010·Journal of the American College of Nutrition·Berdine R MartinConnie M Weaver
Dec 6, 2006·Expert Review of Neurotherapeutics·Neal M DaviesKarina R Vega-Villa
May 11, 2011·Scandinavian Journal of Gastroenterology·Michael DallJesper Hallas
Aug 30, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Yun Jeong Lim, Su Jin Hong

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