Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process

Journal of Gastric Cancer
Da Hyun JungHyojin Park

Abstract

The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age- and sex-matched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Open-type atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous ...Continue Reading

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Citations

May 30, 2019·Journal of Evaluation in Clinical Practice·Fangfang FanHongtao Zhang
Nov 19, 2019·BioMed Research International·Lan Li, Chaohui Yu
Nov 23, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Goh Eun ChungJoo Sung Kim
Sep 10, 2020·Endoscopy International Open·Michele Oliveira De MarcoEduardo Guimarães Hourneaux de Moura

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