PMID: 8971300Dec 1, 1996Paper

Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin

Alimentary Pharmacology & Therapeutics
G CammarotaG Gasbarrini

Abstract

To evaluate and compare two 1-week low-dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori. Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups: (A) (LAC; n = 35) lansoprazole 30 mg once daily, amoxycillin 1000 mg b.d., clarithromycin 250 mg b.d., all for 7 days; and (B) (LAA; n = 35) lansoprazole 30 mg once daily and amoxycillin 1000 mg b.d., both for 7 days, plus azithromycin 500 mg once daily for only 3 days. The H. pylori status was evaluated by means of histology and rapid urease test at entry and 8 weeks after treatment. Three patients did not complete the treatment: one in the LAC group was withdrawn owing to severe side-effects; two patients in the LAA group stopped the treatment prematurely. H. pylori eradication was obtained in 28 of 34 (82%; 95% CI = 66-93%) patients in the LAC group and in 20 of 33 (61%; 95% CI = 42-77%) patients in the LAA group. The difference is significant (P < 0.029). On intention-to-treat analysis, the rates of eradication were (28 of 35 patients, 80% in the LAC group and 20 of 35 patients, 57% in the LAA group. Side-effects occurred in nine (26%)...Continue Reading

Citations

Feb 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F SzczebaraM O Husson
Feb 20, 2002·British Journal of Clinical Pharmacology·F A Al-EidanJ B McConnell
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·G A PipkinJ R Wood
Jan 9, 1999·Alimentary Pharmacology & Therapeutics·W D CheyJ Scheiman
Mar 19, 2003·Journal of Clinical Gastroenterology·G K AnagnostopoulosD Arvanitidis
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Shahram AgahBabak Abbaszadeh
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·P MalfertheinerU Peitz
Apr 14, 1999·The American Journal of Gastroenterology·L LaineG Neil
Jun 4, 1999·Journal of Gastroenterology and Hepatology·A PilottoG Valerio
May 7, 1998·Alimentary Pharmacology & Therapeutics·H J O'ConnorK Cunnane

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