Helicobacter pylori eradication with a 7-day low-dose triple therapy in hemodialysis patients.

Clinical and Experimental Nephrology
Won-Chul ChangChoon-Jo Jin

Abstract

The optimal therapeutic regimen for Helicobacter pylori (H. pylori) infection has not been established in end-stage renal disease (ESRD) patients receiving hemodialysis. We investigated the efficacy and safety of a 7-day omeprazole-based triple therapy with low doses of amoxicillin and clarithromycin (OAC) for eradication of H. pylori infection in ESRD patients receiving hemodialysis. Thirty-three hemodialysis patients and 55 patients with normal renal function underwent upper gastrointestinal endoscopy. For eradication of H. pylori infection, a 7-day triple therapy with low-dose OAC (omeprazole 40 mg daily, amoxicillin 500 mg daily, and clarithromycin 500 mg daily) regimen was used. Four weeks after the completion of the OAC regimen, the success of the H. pylori eradication therapy was determined by histological examination and rapid urease test. The prevalence of H. pylori infection was 36.4% in hemodialysis patients and 65.5% in non-uremic patients (p = 0.0150). The mean duration of hemodialysis in H. pylori-positive and -negative patients was 56.8 ± 26.9 versus 66.4 ± 26.1 months, respectively (p = 0.3196). Eradication was successful in 83.4% of hemodialysis patients and 81.0% of non-uremic patients (p = 1.000). All patient...Continue Reading

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Citations

Dec 7, 2013·Gastroenterology Research and Practice·Min GuGuoxin Zhang
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Shen-Shong Chang, Hsiao-Yun Hu
Mar 16, 2017·World Journal of Gastroenterology : WJG·Karn WijarnpreechaWisit Cheungpasitporn
Apr 25, 2018·World Journal of Gastroenterology : WJG·Mitsushige SugimotoAkira Andoh

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