Helicobacter pylori in Dyspepsia: Phenotypic and Genotypic Methods of Diagnosis

Journal of Global Infectious Diseases
Vignesh ShettyRamachandra Lingadakai

Abstract

Helicobacter pylori affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with chronic gastritis, ulcer disease (gastric and duodenal), mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients. Patients with complaints of abdominal pain, discomfort, acidity, and loss of appetite were chosen for endoscopy, detailed history was contained, and a physical examination was conducted before endoscopy. Biopsies (antrum + body) were received from each patient and subjected to rapid urease test (RUT), histopathological examination (HPE), polymerase chain reaction (PCR), and culture. Of the total 223 biopsy specimens obtained from dyspeptic patients, 122 (54.7%) were positive for H. pylori for HPE, 109 (48.9%) by RUT, 65 (29.1%) by culture, and 117 (52.5%) by PCR. The specificity and sensitivity were as follows: RUT (99% and 88.5%), phosphoglucosamine mutase PCR assay (100% and 95.9%), and culture (100% and...Continue Reading

References

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Mar 4, 2014·World Journal of Gastroenterology : WJG·Elvira Garza-GonzálezFrancisco Javier Bosques-Padilla

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Citations

Mar 15, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Nayanum PokhrelNarayan Raj Bhattarai
Apr 17, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Parvin BahmaninejadBehzad Badakhsh
Jun 27, 2021·Indian Journal of Medical Microbiology·Vignesh ShettyMamatha Ballal

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Methods Mentioned

BETA
biopsies
PCR
biopsy

Software Mentioned

SPSS Statistics

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