Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms

Molecular Immunology
Annika RaitalaM Hurme

Abstract

The chronic gastric infection caused by Helicobacter pylori is known to be associated with several, probably interrelated, immunomodulatory effects, such as protection from atopic diseases, induction of CD4+ CD25+ T regulatory (T(reg)) cells and increase in indoleamine-pyrrole 2,3-dioxygenase (IDO) -dependent suppressive mechanisms. As these mechanisms, as well as the strength of the infection, are very probably genetically controlled, we selected candidate genes (TGFB1, CTLA4) known to be involved in the activation of T(reg) cells. We examined the association of their polymorphisms (TGFB1 C-509T, CTLA4 A+49G) with blood IDO activity in H. pylori seropositive individuals. Genotypes were determined from 391 healthy adults. H. pylori infection was verified by detecting H. pylori IgG antibodies in sera. Concentrations of tryptophan (trp) and kynurenine (kyn), the main metabolite, were determined by reverse-phase high-performance liquid chromatography, and kyn/trp ratio was used as an indicator of IDO activity. The activity was higher in H. pylori seropositive individuals, but this increase was only detected in individuals with CTLA4+49 AA genotype or in carriers of TGFB1-509 allele T. This suggests that H. pylori induced IDO activ...Continue Reading

Citations

Jan 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rainer H Straub
Oct 1, 2011·Zeitschrift für Rheumatologie·R H Straub
May 13, 2009·American Journal of Therapeutics·Joseph Prandota
Jan 30, 2015·Jundishapur Journal of Microbiology·Mehrdad HajilooiAli Reza Khalilian
Mar 5, 2015·Infectious Diseases·Adel SepanjniaFatemeh Dahmardeh
Nov 20, 2015·Frontiers in Cellular and Infection Microbiology·Nianshuang LiNong-Hua Lu
Oct 11, 2007·Helicobacter·Mario Milco D'Elios, Leif P Andersen
Aug 2, 2015·Seminars in Cancer Biology·Joseph G Taylor, John G Gribben
Apr 20, 2013·Brain, Behavior, and Immunity·Aye Mu MyintMarkus J Schwarz
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti

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