Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike

World Journal of Gastrointestinal Oncology
Natale FiguraAntonio Ponzetto

Abstract

Gastric carcinoma (GC) develops in only 1%-3% of Helicobacter pylori (H. pylori) infected people. The role in GC formation of the bacterial genotypes, gene polymorphisms and host's factors may therefore be important. The risk of GC is enhanced when individuals are infected by strains expressing the oncoprotein CagA, in particular if CagA has a high number of repeats containing the EPIYA sequence in its C'-terminal variable region or particular amino acid sequences flank the EPIYA motifs. H. pylori infection triggers an inflammatory response characterised by an increased secretion of some chemokines by immunocytes and colonised gastric epithelial cells; these molecules are especially constituted by proteins composing the interleukin-1beta (IL-1β) group and tumour necrosis factor-alpha (TNF-α). Polymorphisms in the promoter regions of genes encoding these molecules, could account for high concentrations of IL-1β and TNF-α in the gastric mucosa, which may cause hypochlorhydria and eventually GC. Inconsistent results have been attained with other haplotypes of inflammatory and anti-inflammatory cytokines. Genomic mechanisms of GC development are mainly based on chromosomal or microsatellite instability (MSI) and deregulation of sig...Continue Reading

Citations

May 18, 2017·Expert Review of Proteomics·Giulia BernardiniAnnalisa Santucci
Jul 25, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jung Yeon KimKyeongmee Park
Oct 21, 2017·Alimentary Pharmacology & Therapeutics·A Ponzetto, N Figura
Apr 4, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Taweesak TongtaweeSukij Panpimanmas
Aug 23, 2019·World Journal of Gastroenterology : WJG·Anca NegovanClaudia Bănescu
Jul 17, 2020·The Application of Clinical Genetics·Muhamad Ali K ShakhatrehMahmoud Mahafdah
Sep 4, 2020·FEMS Microbiology Reviews·Florent AilloudSebastian Suerbaum
Mar 6, 2021·The Cell Surface·Paula Parreira, M Cristina L Martins

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