Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

World Journal of Gastroenterology : WJG
Kazuya OkushinKazuhiko Koike

Abstract

Both Helicobacter pylori (H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and hepatocellular carcinoma (HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, negative correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study has revealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. p...Continue Reading

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Citations

Aug 11, 2020·World Journal of Clinical Cases·Ru ZhengHua-Jie Cai
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Xue FengQiling Li
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May 3, 2019·Metabolism: Clinical and Experimental·Alessandro MantovaniGiovanni Targher

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BETA
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transgenic

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