Helicobacter pylori Infection and Risk of Lung Cancer: A Meta-Analysis

Lung Cancer International
Pulikonda Mounika

Abstract

Background. Recent evidence showed that Helicobacter pylori seropositivity is a risk factor for gastric and several other cancers. However, evidence on H. pylori infection and risk of lung cancer has been controversial, with a limited number of underpowered studies. We therefore examined the association between H. pylori infection and risk of lung cancer. Methods. A comprehensive literature search was performed using PubMed, EMBASE (until October 2012) for studies investigating an association between Helicobacter pylori (H. pylori) infection and risk of lung cancer. Pooled odds ratio (OR) was calculated using random-effects model. Subgroup and sensitivity analysis were also done. Results. A total of seven studies (6 case-control and 1 cohort study) were included for the analysis. There was a significant heterogeneity among the studies, but no publication bias was observed. We found that H. pylori infection was associated with significantly increased risk of lung cancer (pooled OR, 2.29 (95% CI, 1.34-3.91) P = 0.01). Conclusions. Our meta-analysis suggests a significant increased risk of lung cancer in patients with H. pylori infection. Further research is needed to confirm these findings and to identify the underlying biologica...Continue Reading

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Citations

Apr 13, 2019·Journal of Cellular Biochemistry·Abolfazl Zendehdel, Maryam Roham
Jun 15, 2017·Frontiers in Microbiology·Nerea Fernández de Larrea-BazNuria Aragonés
Mar 7, 2021·Diagnostics·Qixin LengFeng Jiang
Dec 12, 2020·Journal of Pediatric Gastroenterology and Nutrition·Necati BalamtekinMustafa Gülşen

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Methods Mentioned

BETA
Assay
lavage

Software Mentioned

PRISMA
Comprehensive Meta - Analysis

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