PMID: 28502154Jan 1, 2016Paper

Helicobacter pylori Infection as a Risk Factor in Patients Suffering from Food Allergy and Urticaria

The Egyptian Journal of Immunology
Reham M Shabrawy, Khalid Gharib

Abstract

H. pylori infection is common worldwide. Many intestinal and extra intestinal manifestations have been associated with H. pylori infection. H. pylori destruct the gastric lining which allows food allergens to get access to blood, predisposing to Food allergy. Previous works considered chronic urticaria as a known symptom for food allergy and a skin manifestation for H. pylori infection. The aim of this work is to provide evidence based recommendation for detecting H. pylori antigen in stool in patient suffering from both food allergy and chronic urticaria. We determined the frequency of H. pylori Ag in stool in a group of patients complaining from both disorders and compared it with a group of apparently healthy control subjects with no history of either urticaria or food allergy. Our results showed that the frequency of H. pylori Ag in stool in control group was 62.5 %, while, it was 97 % in patient group. When we calculated the risk of H. pylori infection in predisposing to both disorders, odds ratio was 18.6. According to these results we concluded that H. pylori is a risk factor for developing chronic urticaria and food allergy and we recommend testing for H. pylori Ag in stool in patients complaining from these disorders.

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