Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice

Scientific Reports
Yalda KhosraviJamuna Vadivelu

Abstract

Helicobacter pylori, is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori. Despite H. pylori-infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional s...Continue Reading

References

Oct 1, 1975·Laboratory Animals·M E Coates
Sep 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C R Vaillant, P K Lund
Sep 2, 1998·Nature·A BadoM J Lewin
Aug 9, 2002·Nature·Rachel L BatterhamStephen R Bloom
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S MargeticR A Hill
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·D M Pritchard, S M C Przemeck
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan D RothAlain D Baron
May 24, 2008·Science·Ruth E LeyJeffrey I Gordon
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Jan 14, 2011·Annual Review of Medicine·Giovanni MussoMaurizio Cassader
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rochellys Diaz HeijtzSven Pettersson
Apr 15, 2011·BMC Gastroenterology·Fritz FrancoisMartin J Blaser
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Andrew Y Wang, David A Peura
Jan 18, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H H NielsenB Ritz
Apr 24, 2012·Biological Psychiatry·Sarah J SpencerZane B Andrews
May 17, 2012·PLoS Pathogens·Yoshan MoodleyMark Achtman
May 11, 2013·Current Biology : CB·Adam P ChambersRandy J Seeley
May 17, 2014·Alimentary Pharmacology & Therapeutics·N LenderG J Holtmann

❮ Previous
Next ❯

Citations

Sep 16, 2015·Helicobacter·Dionyssios N SgourasYoshio Yamaoka
Jul 13, 2016·Cellular Microbiology·Pierre LarraufieHervé M Blottière
Sep 30, 2016·Microorganisms·Yao-Jong Yang, Bor-Shyang Sheu
Mar 5, 2016·World Journal of Gastroenterology : WJG·Myong Ki BaegMyung-Gyu Choi
Dec 12, 2018·Frontiers in Immunology·Radheshyam MauryaHira L Nakhasi
Apr 17, 2019·Journal of Clinical Medicine·Isabel Cornejo-ParejaFrancisco J Tinahones
Nov 15, 2016·Gastroenterology Research and Practice·Wang-Ping MengMu-Han Lü
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Dayakar AltiSuresh K Kalangi
Nov 15, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gilliard LachJohn F Cryan
Sep 12, 2017·Helicobacter·Jean-Dominique de KorwinAntonio Gasbarrini
Nov 9, 2018·Frontiers in Psychiatry·Rachael Horne, Jane A Foster
May 26, 2017·Frontiers in Microbiology·Dan-Dan ChengNong-Hua Lu
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Samaneh Ostad MohammadiFarshid Kafilzadeh
Jan 23, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Natasha K LeeuwendaalHarriët Schellekens
Sep 12, 2017·Brain, Behavior, and Immunity·Alexandra Castillo-RuizNancy G Forger
Aug 4, 2020·Euroasian Journal of Hepato-gastroenterology·Gokben OzbeyAlfizah Hanafiah

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.