Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function

Helicobacter
Kenneth W SimpsonJ Calam

Abstract

Further elucidation of the consequences of Helicobacter pylori infection on gastric mucosal inflammation and gastric secretory function would be facilitated by an animal model that is susceptible to infection with H. pylori, is broadly similar in gastric physiology and pathology to people, and is amenable to repeated non-invasive evaluation. The goal of this study was to examine the interrelationship of bacterial colonization, mucosal inflammation and gastric secretory function in cats with naturally acquired H. pylori infection. Twenty clinically healthy cats with naturally acquired H. pylori infection (cagA-, picB) and 19 Helicobacter-free cats were evaluated. Gastric colonization was determined by tissue urease activity, light microscopy, culture and PCR. The mucosal inflammatory response was evaluated by light microscopy, and by RT-PCR of the pro-inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNF-alpha in gastric mucosa. Gastric secretory function was assessed by measuring pentagastrin-stimulated acid secretion, fasting plasma gastrin, and antral mucosal gastrin and somatostatin immunoreactivity. H. pylori colonized the pylorus, fundus and cardia in similar density. Bacteria were observed free in the lumen of gastric ...Continue Reading

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Citations

Feb 28, 2003·FEBS Letters·Anne-Christine JauneauMarc Fontaine
Feb 5, 2008·Veterinary Immunology and Immunopathology·Stacey Harbour, Philip Sutton
Oct 11, 2003·Helicobacter·Cuong D TranRoss N Butler
Aug 8, 2014·Frontiers in Immunology·Natalia Castaño-RodríguezHazel M Mitchell
Mar 4, 2009·Journal of Veterinary Science·Heh-Myung GhilCheol-Yong Hwang
Mar 20, 2015·PLoS Neglected Tropical Diseases·Luis Angel VillarElsa Sarti

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