Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function

Kenneth W SimpsonJ Calam


Further elucidation of the consequences of Helicobacter pylori infection on gastric mucosal inflammation and gastric secretory function would be facilitated by an animal model that is susceptible to infection with H. pylori, is broadly similar in gastric physiology and pathology to people, and is amenable to repeated non-invasive evaluation. The goal of this study was to examine the interrelationship of bacterial colonization, mucosal inflammation and gastric secretory function in cats with naturally acquired H. pylori infection. Twenty clinically healthy cats with naturally acquired H. pylori infection (cagA-, picB) and 19 Helicobacter-free cats were evaluated. Gastric colonization was determined by tissue urease activity, light microscopy, culture and PCR. The mucosal inflammatory response was evaluated by light microscopy, and by RT-PCR of the pro-inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNF-alpha in gastric mucosa. Gastric secretory function was assessed by measuring pentagastrin-stimulated acid secretion, fasting plasma gastrin, and antral mucosal gastrin and somatostatin immunoreactivity. H. pylori colonized the pylorus, fundus and cardia in similar density. Bacteria were observed free in the lumen of gastric ...Continue Reading


Nov 1, 1992·Veterinary Pathology·A LeeJ C Murphy
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Aug 1, 1990·Infection and Immunity·M J RadinJ Fox
Apr 1, 1995·Journal of Comparative Pathology·W HermannsJ Lechner
Jul 1, 1995·Infection and Immunity·J G FoxJ C Murphy
Mar 17, 1995·Science·L S Tompkins, S Falkow
Feb 7, 1994·NIH Consensus Statement
May 5, 1994·The New England Journal of Medicine·J ParsonnetG D Friedman
Jun 1, 1994·Infection and Immunity·L K HandtI H Stalis
Feb 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·H M MitchellA Lee
May 1, 1993·Infection and Immunity·A LeeS Hazell
Aug 1, 1995·Alimentary Pharmacology & Therapeutics·K E McColl, E el-Omar
Sep 1, 1995·Journal of Clinical Gastroenterology·J RizzoF Opper
Mar 1, 1996·Gastroenterology·C C McGowanM J Blaser
Jul 1, 1997·Gastroenterology·E M El-OmarK E McColl
Mar 21, 1998·Journal of Clinical Microbiology·R NeigerA Schmassmann

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