Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor--by epithelial cells, T cells, and macrophages--in gastric mucosa

The Journal of Infectious Diseases
Harry Hua-Xiang XiaBenjamin Chun-Yu Wong

Abstract

The macrophage migratory inhibitory factor (MIF) plays a pivotal role in inflammatory and immune diseases; however, its role in gastrointestinal diseases has not been clarified. This study intended to determine the expression of MIF, by gastric epithelial cells, T cells, and macrophages, in Helicobacter pylori-induced gastritis. Sixty-four patients (30 males, 34 females; mean age, 47 years) referred for upper endoscopy were recruited. Biopsy specimens from the gastric antrum and corpus were obtained for (1) detection of H. pylori and histological examination, (2) single and double immunostaining to test for expression of MIF protein in epithelial cells, T cells, and macrophages, and (2) in situ hybridization for expression of MIF mRNA within the lamina propria. In mucosal specimens from each of the 2 sites, both the percentage of MIF(+) epithelial cells and the numbers of MIF mRNA(+) inflammatory cells, MIF(+) T cells, and MIF(+) macrophages were significantly higher in H. pylori-positive patients than in H. pylori-negative patients. Overall, the percentage of MIF(+) epithelial cells and the numbers of MIF mRNA(+) cells, MIF(+) T cells, and MIF(+) macrophages were higher in the antrum than in the corpus. The percentage of MIF(+...Continue Reading

Citations

Jul 21, 2004·Journal of Endourology
Apr 10, 2010·World Journal of Gastroenterology : WJG·Zhong-Wu LiJi-You Li
Jun 1, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Carlos A BarreraVictor E Reyes
Sep 2, 2005·American Journal of Reproductive Immunology : AJRI·Todd M SchaeferCharles R Wira
Sep 24, 2005·Helicobacter·Henrik Permin, Leif P Andersen
Aug 30, 2008·Clinical and Experimental Immunology·S KariyaK Nishizaki
Mar 17, 2009·The American Journal of Pathology·Benny L W WongHui Yao Lan
Jul 20, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K TriantafyllouG D Dimitriadis
Apr 1, 2005·World Journal of Gastroenterology : WJG·Harry Hua-Xiang XiaBenjamin Chun-Yu Wong
Jul 15, 2015·World Journal of Gastroenterology : WJG·Anastasia KourikouKonstantinos Triantafyllou
Sep 18, 2015·World Journal of Gastroenterology : WJG·Long-Jun HeSen-Lin Zhu
Apr 5, 2020·Tropical Medicine and Infectious Disease·Thomas Holowka, Richard Bucala
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Lidia Szulc-DąbrowskaFelix N Toka

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