Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus

The American Journal of Gastroenterology
H H XiaMichael Horowitz

Abstract

The association between Helicobacter pylori (H. pylori) infection and diabetes mellitus is controversial. We aimed to determine the prevalence of H. pylori infection in patients with diabetes and nondiabetic controls, and assess whether H. pylori infection was associated with upper gastrointestinal (GI) symptoms in diabetes mellitus. A total of 429 patients with type 1 (n = 49) or type 2 (n = 380) diabetes mellitus (48.6% women, mean age 60.7 yr) and 170 nondiabetic controls (34.7% women, mean age 60.4 yr) were evaluated. All subjects completed a validated questionnaire (the Diabetes Bowel Symptom Questionnaire) to determine upper GI symptoms, and a blood sample was tested for H. pylori infection using a validated ELISA kit (sensitivity 96%, specificity 94%). Seroprevalence of H. pylori was 33% and 32%, respectively, in patients with diabetes and controls (NS). In both groups, the seroprevalence was significantly higher in men than in women; 39% vs 25% (p = 0.002) in diabetic patients, and 40% vs 20% (p = 0.01) in controls. Patients with diabetes had a significantly higher prevalence of early satiety (OR = 2.30), fullness (OR = 3.15), and bloating (OR = 1.50) compared with controls. Upper GI symptoms were present in 49% of H. p...Continue Reading

References

Nov 1, 1991·Diabetes Care·W RathmannF A Gries
Jan 1, 1989·Digestive Diseases·N J Talley
Oct 15, 1989·Annals of Internal Medicine·N J TalleyA R Zinsmeister
Mar 1, 1983·Annals of Internal Medicine·M Feldman, L R Schiller
Dec 1, 1995·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·R WredlingJ Ostman
Mar 1, 1996·Digestive Diseases and Sciences·B OldenburgJ B Hoekstra
May 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·E SchvarczC Berne
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M MałleckiJ Sieradzki
May 23, 1998·Diabetes Research and Clinical Practice·D A de LuisD Boixeda
Sep 16, 1998·Journal of Gastroenterology and Hepatology·S K Lam, N J Talley
Dec 17, 1998·European Journal of Gastroenterology & Hepatology·A GasbarriniG Gasbarrini
Dec 24, 1998·The New England Journal of Medicine·K McCollT Hilditch
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·S SalardiD Vaira
Jun 22, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·N GüvenerO Gedik
Aug 13, 1999·European Journal of Gastroenterology & Hepatology·A GasbarriniG Gasbarrini
Sep 7, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·G T KoC S Cockram
Sep 28, 1999·Scandinavian Journal of Gastroenterology·A M Caballero-PlasenciaJ M Esteban-Carretero
Jan 15, 2000·Scandinavian Journal of Gastroenterology·A SpångéusF Lithner

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Citations

Mar 20, 2012·The Journal of Infectious Diseases·Yu Chen, Martin J Blaser
Nov 6, 2008·World Journal of Gastroenterology : WJG·Guilherme-Eduardo-Goncalves FelgaJaime-Natan Eisig
Jun 13, 2009·World Journal of Gastroenterology : WJG·Konstantinos X PapamichaelGerassimos J Mantzaris
May 2, 2014·World Journal of Gastroenterology : WJG·Cong HeNong-Hua Lu
Jan 23, 2009·Digestive Diseases and Sciences·Donald Garrow, Mark H Delegge
Feb 23, 2012·Diabetes Care·Christopher K RaynerMichael Horowitz
Jan 27, 2012·Diabetes Care·Christie Y JeonAllison E Aiello
Feb 7, 2006·Disease-a-month : DM·Ellen C Ebert
Apr 16, 2004·Journal of Pediatric Gastroenterology and Nutrition·Marcello CandelliAntonio Gasbarrini
Feb 20, 2003·The American Journal of Gastroenterology·Nicholas J Talley
Feb 14, 2017·Journal of Translational Internal Medicine·Armando PeixotoJoão Santos-Antunes
Mar 29, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·M HorowitzM Samsom
Sep 10, 2013·Genetic Testing and Molecular Biomarkers·Mohammad Taher MoradiAnna Rafiei Hashtchin
Oct 14, 2016·PloS One·Susheela D Biranjia-Hurdoyal, Sharmila P Seetulsingh-Goorah
Oct 3, 2002·The American Journal of Gastroenterology·Akira KawamuraYoshikazu Kinoshita
Oct 9, 2018·Minerva gastroenterologica e dietologica·Stella I SmithRinaldo Pellicano
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·P L LutseyA R Folsom
Jan 8, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·K SchimkeT M E Davis
Sep 2, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·H Y JinT S Park
Nov 26, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Hyun KimUNKNOWN Korean Association of Gastroenterology
Jun 20, 2020·Helicobacter·Melih Tansel Gökışık, Seyit Uyar
Apr 16, 2014·Journal of Gastroenterology and Hepatology·Gi-Hua YangChih-Jen Chang
Jun 15, 2005·Journal of Endocrinological Investigation·N E GulcelikY Aral
Dec 8, 2015·World Journal of Gastroenterology : WJG·Zhen YangNong-Hua Lu
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Mohammad Reza Esmaeili DookiMohammad Pournasrollah
Apr 30, 2003·World Journal of Gastroenterology : WJG·Mehmet SargýnAli Yayla
Sep 13, 2002·European Journal of Internal Medicine·Roussos AnastasiosAngeliki Ferti
Mar 19, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sherifa Ahmed HamedMohamed S Abdel Rahman

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