Helicobacter pylori infection: Review and practice

La Presse médicale
F Mégraud

Abstract

Helicobacter pylori is the source of a frequent stomach infection that can lead to serious diseases such as gastroduodenal ulcer diseases and gastric cancers (carcinoma and MALT lymphoma). H. pylori is generally acquired in early childhood and persists throughout life, unless specifically eradicated by antibiotics. It is the first bacteria recognized as able to cause gastric cancer. Its eradication at an early stage cures MALT lymphoma. Among the numerous and reliable diagnostic methods, the urea breath test is the most accessible in daily practice. The current treatment for this infection consists in the administration of two antibiotics: clarithromycin and amoxicillin with an antisecretory agent to increase pH, for at least 7days. The rising rate of treatment failure following increasing resistance to clarithromycin has generated new protocols of antibiotic therapy. A policy for gastric cancer prevention by eradication ofH. pylori is currently being debated.

References

Jul 12, 1975·Lancet·P CorreaM Archer
Aug 27, 1999·BMJ : British Medical Journal·P DominiciE Grossi
Jul 30, 2002·QJM : Monthly Journal of the Association of Physicians·R F HarveyJ Donovan
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Benjamin Chun-Yu WongUNKNOWN China Gastric Cancer Study Group
Feb 8, 2007·Emerging Infectious Diseases·Sharon PerryJulie Parsonnet
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
Jan 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Naomi OhnishiMasanori Hatakeyama

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Citations

Oct 20, 2012·World Journal of Gastroenterology : WJG·Rodrigo Buzinaro SuzukiMárcia Aparecida Sperança
Jul 15, 2015·Terapevticheskiĭ arkhiv·O K PozdeevR G Saifutdinov

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