Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Journal of Reproductive Immunology
Simona CardaropoliTullia Todros

Abstract

The relationship between Helicobacter pylori infection and extragastric disease is well established. This study prospectively investigated whether maternal H. pylori seropositivity, detected during the first half of pregnancy, could be associated with the development of the major pregnancy-related pathological conditions during the late second or third trimester in a general population. Our hypothesis was that H. pylori infection might negatively influence pregnancy development and outcome. A total of 2820 consecutive pregnant women were recruited before 20 weeks' gestation, from October 2008 to August 2010, and blood samples were collected from each subject. IgG antibodies against H. pylori were assayed in maternal serum by a commercial immunoassay. Logistic regression analyses were performed to assess any association between H. pylori seropositivity and adverse pregnancy outcomes. Gestational diabetes mellitus (GDM) was the most common maternal complication (5.7%) and the only pregnancy-related disorder with a significantly higher rate of H. pylori-positive women (41.3%) compared with subjects who did not develop the disease (27.7%; P < 0.001; OR = 1.829, 95% CI = 1.320-2.533). The difference observed remained statistically s...Continue Reading

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Citations

Jun 2, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Woo YangHan Sung Hwang
Aug 18, 2016·Helicobacter·Elisabetta Goni, Francesco Franceschi
Feb 2, 2018·International Journal of Clinical Practice·Ioannis BellosVasilios Pergialiotis
Jan 23, 2018·Frontiers in Medicine·Louise C Kenny, Douglas B Kell
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny
Jul 5, 2021·International Journal of Clinical Practice·Yingjie TangZongjie Lv

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