Helicobacter species are associated with possible increase in risk of hepatobiliary tract cancers

Surgical Oncology
Manoj Pandey, Mridula Shukla

Abstract

Attempts at early identification of hepatobiliary cancers have failed due to non-availability of a sensitive test. Prevention offers the best chance to reduce the morbidity and mortality from these. Identification of an etiological agent and especially if the potentially identified cause can be eradicated like Helicobacter sp. infection, will not only reduce incidence but also the mortality. This article reviews 15 studies on Helicobacter species in hepatobiliary cancers identified on pubmed, scopus and google scholar search. Of these, Five were single group and 10 were case control. These 10 case control studies were included in the meta analysis, which was carried out using odds ratio and both a fixed and random effect model, 95% confidence intervals for odds ratio was calculated. Chi square test for heterogeneity was employed. The overall effect was calculated using Z test. The cumulative sample size of cases was 205, of which 115 were positive (56%) for Helicobacter, while among 263 controls 53 (20%) were found to be positive for Helicobacter infection. The positivity rate in case control studies was higher than that observed in single group studies. The cumulative odds ratio for the study sample was 8.72 (95% CI 4.78-15.91...Continue Reading

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Citations

Feb 22, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Virinder Kumar BansalSushma Sagar
Dec 10, 2009·Future Microbiology·Quoc V TuGeorge L Mendz
Feb 5, 2011·Cirugía española·Encarna VelázquezAlberto Gómez-Alonso
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Sep 16, 2011·Helicobacter·Annemieke SmetGeorgina L Hold
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Tadashi ShimoyamaShinsaku Fukuda
Jan 1, 2014·International Journal of Clinical Practice·M XiaoY Wang
Feb 11, 2015·World Journal of Gastroenterology : WJG·Fany Karina Segura-LópezJavier Torres
Sep 4, 2015·World Journal of Hepatology·Marek WalugaRafał Kotulski
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Soraya J KaewpitoonNatthawut Kaewpitoon
Jan 26, 2020·World Journal of Surgical Oncology·Huisong LeeWon Hee Lee

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