PMID: 9418957Jan 7, 1998Paper

Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development

Journal of Neuroscience Research
H J StewartK R Jessen

Abstract

Although basic helix-loop-helix (bHLH) proteins play an important role in transcriptional control in many cell types, the role of HLH proteins in Schwann cells has yet to be assessed. In this study, we have analyzed the expression of the dominant negative HLH genes, Id1 to Id4 and the class A gene REB, during Schwann cell development. We found that mRNA derived from these genes was present in the Schwann cell lineage throughout development including embryonic precursors and mature cells. The mRNA levels were not significantly regulated during development. Nevertheless, by using antibodies against the four different Id proteins, we found clear regulation of some of these genes at the protein level, in particular Id 2, 4, and REB, both in amount and nuclear/cytoplasmic localization. All these proteins are found in the nuclei of Schwann cell precursors but are not seen in nuclei of Schwann cells of newborn nerves. We observed extensive overlap in Id expression, especially in Schwann cell precursors that co-expressed all four Id proteins and REB. We also showed that Id 1 and 2 were up-regulated as Schwann cells progressed through the cell cycle. These data indicate that HLH transcription factors act as regulators of Schwann cell de...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J E Bottenstein, G H Sato
Oct 1, 1992·Current Opinion in Neurobiology·K R Jessen, R Mirsky
Dec 20, 1992·Journal of Molecular Biology·S Seetharam, M M Seidman
Mar 1, 1992·The Journal of Cell Biology·R CurtisK R Jessen
Aug 25, 1991·Nucleic Acids Research·Y ZhangM Bina
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Nov 1, 1995·Molecular and Cellular Biology·A ChiaramelloT Neuman
Jul 26, 1996·Science·M JaegleD Meijer
Sep 6, 1996·The Journal of Biological Chemistry·A ChiaramelloM X Zuber
Feb 1, 1996·Current Opinion in Neurobiology·R Mirsky, K R Jessen
Sep 27, 1996·The Journal of Biological Chemistry·R W DeedJ D Norton
Mar 1, 1996·The European Journal of Neuroscience·H J StewartR Mirsky
Jan 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y JenR Benezra
Jan 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M K DuncanK K Chada
Feb 1, 1997·Current Opinion in Neurobiology·J E Lee

❮ Previous
Next ❯

Citations

May 6, 2008·The Journal of Biological Chemistry·Gennifer M MagerJohn Svaren
Apr 12, 2012·Nucleic Acids Research·Rajini SrinivasanJohn Svaren
Apr 30, 2015·Glia·Kelly R MonkCarla Taveggia
Jun 19, 2008·Differentiation; Research in Biological Diversity·Jeffrey D StevensMichael K Skinner
Feb 3, 2000·Molecular and Cellular Neurosciences·P ThatikuntaJ L Rutkowski
Nov 11, 2017·Glia·Jorge B Aquino, Romina Sierra
Jul 22, 1998·Microscopy Research and Technique·K R Jessen, R Mirsky
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nigel L Hammond, Colin A B Jahoda
Mar 24, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Xiaodong ZhengKeping Chen
Dec 3, 1999·Journal of Neurochemistry·S M Dashiell, C L Koski
Apr 29, 1999·Brain Pathology·R Mirsky, K R Jessen
Feb 19, 2000·Journal of Neuroscience Research·M ScarlatoD Pleasure
Aug 11, 1999·Trends in Neurosciences·K R Jessen, R Mirsky
Jan 18, 2005·Journal of Theoretical Biology·Olivier Cinquin, Jacques Demongeot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.