Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins

Trends in Biochemical Sciences
K Struhl

Abstract

Four distinct structural motifs have been proposed for the DNA-binding domains of eukaryotic transcriptional regulatory proteins; the helix-turn-helix, two kinds of zinc finger, and the leucine zipper. Within each structural motif, there are often families of related proteins that recognize similar DNA sequences and are conserved throughout the eukaryotic kingdom. However, the processes of transcriptional activation and repression appear to be independent of the specific type of protein-DNA interaction.

Citations

Jul 1, 1993·Protein Science : a Publication of the Protein Society·J C HuR T Sauer
Jan 1, 1991·Progress in Biophysics and Molecular Biology·B S Shastry
Jan 1, 1991·Pharmacology & Therapeutics·Y S Cho-ChungH Yokozaki
Sep 1, 1991·Brain Research. Molecular Brain Research·M SimonatoJ O McNamara
Jul 1, 1991·Research in Microbiology·N L Brown, L R Evans
Sep 1, 1993·Mechanisms of Development·B Kalionis, P H O'Farrell
Jun 1, 1990·Current Opinion in Cell Biology·J T Kadonaga
Jan 1, 1991·Trends in Biochemical Sciences·M BaronI D Campbell
Dec 1, 1996·International Journal of Biological Macromolecules·D K Chang, S F Cheng
Sep 11, 1999·Breast Cancer Research and Treatment·D A KirschmannM J Hendrix
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C G BurdG Dreyfuss
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M AffolterW J Gehring
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P B Zhou, D J Thiele
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C T DameronD Hamer
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J Hakes, R Berezney
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R MeyerC Scheidereit
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M LipkinM G Rosenfeld
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Schena, R W Davis
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·P TranqueV P Mauro
Apr 29, 2009·The Journal of Experimental Medicine·Sotiria TzimaGeorge Kollias
Jul 25, 1990·Nucleic Acids Research·J BernuésF Azorín
Apr 11, 1990·Nucleic Acids Research·D Ghosh

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