Helminth-induced regulatory T cells and suppression of allergic responses

Current Opinion in Immunology
Jayden LoganPaul Giacomin

Abstract

Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regulatory T cell expansion or effector functions through either direct (secretion of excretory/secretory molecules) or indirect mechanisms (regulation of the microbiome). This review will discuss key findings from human immunoepidemiological observations, studies using animal models of disease, and clinical trials with live worm infections, discussing the therapeutic potential for worms and their secreted products for treating allergic inflammation.

Citations

Mar 11, 2020·Immunology·Madeleine P J WhiteRick M Maizels
Aug 16, 2018·Frontiers in Immunology·E Jane Homan, Robert D Bremel
Sep 10, 2019·Journal of Cellular and Molecular Medicine·Wenzhe ZhangXuefeng Wang
Nov 15, 2021·International Journal for Parasitology·Alex LoukasPeter J Hotez
Dec 3, 2021·Medical Microbiology and Immunology·Nonthapan PhasukChuchard Punsawad

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