Helminths, hosts, and their microbiota: new avenues for managing gastrointestinal helminthiases in ruminants.

Expert Review of Anti-infective Therapy
Alba CortesCinzia Cantacessi

Abstract

Evidence is emerging of complex interactions occurring between gastrointestinal (GI) parasites of ruminants and the resident gut flora, with likely implications for the pathophysiology of worm infection and disease. Similarly, recent data point toward the occurrence of a GI nematode (GIN)-specific microbiota, with potential roles in worm fundamental physiology and reproduction. Parasite-microbiota relationships might represent potential targets for the development of novel parasiticides. In this article, we review current knowledge of the role(s) that host- and helminth-associated microbiota play in ruminant host-parasite relationships, and outline potential avenues for the control of GIN of farmed ruminants via the manipulation of resident microbial species with putative functions in infection establishment, host-immune modulation, and/or parasite fitness and survival. In order for this knowledge to be translated into practical applications, we argue that several aspects of the nematode-microbiota cross-talk must be addressed, including (i) the causality of interactions between the parasite, the gut microbiota, and the host immune system, (ii) the modes of action of dietary prebiotics and probiotics, (iii) the mechanisms by wh...Continue Reading

References

Apr 1, 1986·Veterinary Parasitology·E M AbbottP H Holmes
Mar 1, 1995·International Journal for Parasitology·K L ShawH S Gill
Sep 29, 1999·International Journal for Parasitology·D C SimcockH V Simpson
Feb 3, 2005·FEMS Microbiology Letters·Nicola D WalkerR John Wallace
Sep 21, 2010·Applied and Environmental Microbiology·S C FernandoU Desilva
Dec 21, 2010·Nature Immunology·Kendle M Maslowski, Charles R Mackay
Mar 29, 2011·Applied and Environmental Microbiology·Chin Giaw LimMattheos A G Koffas
Nov 30, 2011·Nature Reviews. Genetics·Wilfried Weber, Martin Fussenegger
Dec 14, 2011·Veterinary Parasitology·Ray M Kaplan, Anand N Vidyashankar
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Jun 6, 2014·Parasitology·Laura GlendinningFrancisca Mutapi
Sep 30, 2014·Immunology Letters·E J DePeters, L W George
Oct 9, 2014·Parasite : Journal De La Société Française De Parasitologie·Tom N McNeilly, Alasdair J Nisbet
Dec 2, 2014·Pathogens·M Pilar Francino
May 26, 2015·Microbes and Environments·Yutaka UyenoTakeshi Shimosato
Sep 24, 2015·Veterinary Parasitology·Nadino CarvalhoAlessandro F T Amarante
Dec 18, 2015·Drug Design, Development and Therapy·Jean-Yves Trosset, Pablo Carbonell
May 18, 2016·Trends in Parasitology·Magda Vieira BenavidesCurtis Van Tassell
May 31, 2016·Advances in Parasitology·A J NisbetD M Piedrafita
Nov 12, 2016·Microbial Pathogenesis·Emmanouil Angelakis
Jan 27, 2017·Annual Review of Public Health·Samuel S MyersPeter Huybers
Nov 11, 2017·Transboundary and Emerging Diseases·J CharlierE Claerebout
Feb 9, 2018·The Veterinary Clinics of North America. Food Animal Practice·Christopher C L Chase
Feb 27, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yensi Flores BuesoMark Tangney
Mar 13, 2018·Annual Review of Biomedical Engineering·Josef R BoberNikhil U Nair

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.