PMID: 3748849Jan 1, 1986Paper

Helodermin has a VIP-like effect upon canine blood flow

Peptides
S NaruseN Yanaihara

Abstract

The effect of helodermin on vascular physiology was studied in anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dose-dependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd(1-27)NH2 retained substantial activity similar to the full helodermin molecule but the prolonged effect was lost. Hd(7-35) and Hd(22-35) were inactive in this system. Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.

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Citations

Sep 11, 1987·European Journal of Pharmacology·H KoshiyamaH Imura
Jan 16, 1996·Regulatory Peptides·J P Raufman
Dec 14, 1999·European Journal of Pharmacology·Y TanakaK Shigenobu
Jul 6, 2000·European Journal of Biochemistry·M C Vandermeers-PiretP Robberecht
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T GrunditzF Sundler
Sep 20, 2011·The Journal of Clinical Investigation·Mitsuteru AkahoshiStephen J Galli
Dec 27, 2008·Pharmacology & Therapeutics·Louise Dickson, Keith Finlayson
Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R UddmanL Edvinsson
Jan 1, 1988·Annals of the New York Academy of Sciences·P RobberechtJ Christophe
Dec 3, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jean-Philippe Chippaux, Karim Amri
May 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·H C FehmannR Arnold
Apr 24, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Steven D Aird

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