HELP for AML: methylation profiling opens new avenues

Cancer Cell
Lars Bullinger, Scott A Armstrong

Abstract

There is growing evidence that aberrant gene expression in cancer is linked to epigenetic deregulation like promoter cytosine methylation in CpG-islands. In this issue of Cancer Cell, Figueroa et al. show that genome-wide promoter DNA methylation profiling reveals unique AML subgroups and methylation patterns that are associated with clinical outcome.

References

Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Nov 4, 2008·Cancer Cell·Andrei V KrivtsovScott A Armstrong
Mar 27, 2009·Leukemia·T Neff, S A Armstrong

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Citations

Oct 22, 2010·Science Translational Medicine·Jesper B AndersenSnorri S Thorgeirsson
Mar 23, 2011·Biochemistry. Biokhimii︠a︡·E V Chetverina, A B Chetverin
Jan 5, 2011·PLoS Genetics·Hélène Plun-FavreauNicholas W Wood
Nov 16, 2010·Journal of Proteomics·Katarina M JørgensenBjørn Tore Gjertsen
Oct 26, 2010·Oncogene·H HeJ Yan

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