PMID: 6978921Jun 1, 1982Paper

Helper T cell recognition of the variable domains of a mouse myeloma protein (315). Effect of the major histocompatibility complex and domain conformation

The Journal of Experimental Medicine
T Jørgensen, K Hannestad

Abstract

We have examined the recognition of the variable (V) domain of the heavy (VH) and light (V lambda 2) chains of mouse myeloma protein 315 by helper T cells. Mice were primed with the isolated V domain in complete Freund's adjuvant, and carrier (V domain)-primed spleen cells were transferred together with hapten (NIP)-primed spleen cells to recipient mice that were boosted with NIP3-Fab-315. The helper cell response to both domains was governed by H-2-linked immune response (Ir) genes, and VH-315 and V lambda 2 displayed different Ir phenotypes. H-2k conferred high responsiveness to VH on three different genetic backgrounds, BALB/c, C3H, and B10; mice of the d and b haplotypes were low responders. Conversely, H-2d conferred high responsiveness to V lambda 2 on two backgrounds, BALB/c and C3H, whereas mice of the k haplotype were low responders to this domain. Non-H-2 genes of the B10 background extinguished the helper cell response to V lambda 2 in animals with the high responder d haplotype. The VH Ir gene mapped to the K-A interval of the H-2 complex. Unfolded (completely reduced and alkylated) V domains primed helper cells as efficiently as folded domains for responses to NIP3-Fab-315, indicating that the helper cells recogniz...Continue Reading

References

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Citations

Jul 13, 2001·European Journal of Immunology·S K Reitan, K Hannestad
May 21, 2005·Cancer Immunology, Immunotherapy : CII·Håkan Mellstedt, Aniruddha Choudhury
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Weiss, B Bogen
Jun 1, 1991·Scandinavian Journal of Immunology·G F Lauritzsen, B Bogen
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Solveig Klaebo Reitan, Kristian Hannestad
Jun 1, 1984·Immunological Reviews·K Bottomly
May 2, 2014·Frontiers in Immunology·Ole Audun Werner HaabethBjarne Bogen
Jan 1, 1993·International Reviews of Immunology·B Bogen, S Weiss
Jun 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristian Hannestad, Helge Scott
Jun 1, 1995·European Journal of Immunology·S K Reitan, K Hannestad
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·K Hannestad, G Kristoffersen
Nov 1, 1988·European Journal of Immunology·G Kristoffersen, K Hannestad

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