Helper T cell subsets: heterogeneity, functions and development

Veterinary Immunology and Immunopathology
C A LondonA Kelso

Abstract

The discovery that the nature of cytokine production by CD4+ T lymphocytes could drastically alter an immune response led to the categorization of distinct helper T cell subsets, most notably Th1 and Th2. Recent evidence suggests that such helper responses are actually quite heterogeneous and ultimately, the course of an immune response depends upon the predominance of particular cytokines. While the factors leading to the production of individual cytokines are not completely defined, it is clear that the nature and dose of antigen, location of antigen challenge, and genetic composition of the individual all play a role in the process. Elucidating the cellular and molecular pathways responsible for helper T cell differentiation will ultimately permit the manipulation of immune responses to pathogens, as well as the development of novel vaccine strategies.

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Citations

Aug 19, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Edmund J GosselinBibiana V Iglesias
Mar 12, 2003·Veterinary Immunology and Immunopathology·N K BoydJ M Ball
Oct 3, 1999·Veterinary Immunology and Immunopathology·R De LunaD Mancino
Nov 5, 2002·Veterinary Microbiology·John H Wyckoff
Jan 22, 2013·Briefings in Functional Genomics·Michal PolonskyNir Friedman
Nov 10, 2005·Immunology and Cell Biology·Kazuhiko FujitaFujio Suzuki
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Jul 13, 2005·American Journal of Veterinary Research·Lynelle R JohnsonChristian M Leutenegger
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T J NuttallP B Hill
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nadav DujovnyAnita S Chong
Apr 29, 2015·International Immunopharmacology·Ji-Yan SuXiao-Ping Lai
Jan 1, 2013·Brain Sciences·Asa Fex Svennigsen, Lars B Dahlin
Jul 3, 1999·Clinical and Diagnostic Laboratory Immunology·R HarleyM J Day

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