Helper T lymphocyte unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells. Implications for cellular and humoral responses

Transplantation
D K BishopErnst J Eichwald

Abstract

Initial treatment of heterotopic cardiac transplant recipients with anti-CD4 mAb promotes long-term (> 60 days) allograft survival. We have used modified limiting dilution analysis to quantitate donor alloantigen-reactive helper T lymphocytes (HTL) and CTL in mice bearing long-term cardiac allografts. Despite repopulation of lymphoid tissues with CD4+ T cells, donor alloantigen-reactive IL-2 producing and IL-4-producing HTL were rare or not detectable in lymphoid tissues or in the graft. While donor-reactive precursor CTL were present in lymphoid tissues, modified limiting dilution analysis revealed that stimulated ("antigen-conditioned") CTL were not detectable, and few CTL were present in the graft. In addition, antibodies reactive with donor alloantigens were not detectable in the sera of mice bearing long-term cardiac allografts. To determine whether additional in vivo stimulation with donor alloantigens would elicit an immune response, sponge allografts were implanted into mice bearing long-term cardiac allografts. Previous reports from this laboratory have demonstrated that T cell infiltration of sponge allografts is dependent upon antigen-driven cytokine production. While third-party sponge allografts were readily infilt...Continue Reading

Citations

Jul 1, 1996·Trends in Cardiovascular Medicine·L A DebruyneD K Bishop
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Meera J NathanD Keith Bishop
Aug 1, 1997·Nature Medicine·H AraiG J Nabel
Jan 27, 1997·Transplantation·S D BergeseC G Orosz
Apr 13, 2004·Transplantation·A Benedict Cosimi, David H Sachs
Jan 1, 1996·International Reviews of Immunology·O J FinnD K Bishop
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A DiazD K Bishop
Nov 5, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas HaudebourgBernard Vanhove
Oct 3, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S C WoodD K Bishop
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K CsencsitsD K Bishop
Oct 1, 2011·The Journal of Pathology·Adam J BoothD Keith Bishop
Oct 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J BoothD K Bishop
Mar 5, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G SchiechlM Mack
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergio A QuezadaRandolph J Noelle
May 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saidou BalamMatthias Mack
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A A BickerstaffC G Orosz
Feb 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sherri WoodIvan Maillard
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan M FaustD Keith Bishop
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryna E BurrellD Keith Bishop
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan M FaustD Keith Bishop
Oct 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam Jared BoothD Keith Bishop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.