Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis

Therapeutic Advances in Musculoskeletal Disease
Franziska DurchscheinAndreas Eherer

Abstract

Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurr...Continue Reading

References

Oct 19, 2006·Seminars in Arthritis and Rheumatism·Stavros K NtoumaziosDimitrios A Assimakopoulos
Jun 29, 2015·Clinics in Plastic Surgery·Guy MagalonBrigitte Granel
Feb 28, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J N KimmelJ E Pandolfino

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