Helsinki Stroke Model Is Transferrable With "Real-World" Resources and Reduced Stroke Thrombolysis Delay to 34 min in Christchurch

Frontiers in Neurology
Teddy Y WuJohn Fink

Abstract

Christchurch hospital is a tertiary hospital in New Zealand supported by five general neurologists with after-hours services provided mainly by onsite non-neurology medical residents. We assessed the transferrability and impact of the Helsinki Stroke model on stroke thrombolysis door-to-needle time (DNT) in Christchurch hospital. Key components of the Helsinki Stroke model were implemented first in 2015 with introduction of patient pre-notification and thrombolysis by the computed tomography (CT) suite, followed by implementation of direct transfer to CT on ambulance stretcher in May 2017. Data from the prospective thrombolysis registry which began in 2012 were analyzed for the impact of these interventions on median DNT. Between May and December 2017, 46 patients were treated with alteplase, 25 (54%) patients were treated in-hours (08:00-17:00 non-public holiday weekdays) and 21 (46%) patients were treated after-hours. The in-hours, after-hours, and overall median (interquartile range) DNTs were 34 (28-43), 47 (38-60), and 40 (30-51) minutes. The corresponding times in 2012-2014 prior to interventions were 87 (68-106), 86 (72-116), and 87 (71-112) minutes, representing median DNT reduction of 53, 39, and 47 minutes, respective...Continue Reading

References

Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
May 25, 2012·Neurology·Atte MeretojaMarkku Kaste
Nov 10, 2012·Stroke; a Journal of Cerebral Circulation·Andria L FordJin-Moo Lee
Jan 9, 2014·Stroke; a Journal of Cerebral Circulation·Ilana M RuffLee H Schwamm
Mar 15, 2014·Stroke; a Journal of Cerebral Circulation·Atte MeretojaLeonid Churilov
Jun 20, 2015·Journal of Neurointerventional Surgery·Leslie BusbyRishi Gupta
Jul 7, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Leanne K CasaubonUNKNOWN Heart and Stroke Foundation of Canada Canadian Stroke Best Practices Advisory Committee
Aug 13, 2015·Cerebrovascular Diseases Extra·Sander M Van SchaikNyika D Kruyt
Dec 22, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Bing Yu ChenAlexandre Y Poppe
Jul 2, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paolo CandelaresiF Frediani
Jul 7, 2017·Neurology. Clinical Practice·Ilana M RuffShyam Prabhakaran
Nov 16, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Noreen KamalMichael D Hill

❮ Previous
Next ❯

Citations

Jul 13, 2019·Frontiers in Neurology·Ferghal McVerryMark O McCarron
Mar 27, 2020·Stroke; a Journal of Cerebral Circulation·James BeharryTeddy Y Wu
Sep 20, 2018·Current Neurology and Neuroscience Reports·Paula Muñoz VenturelliPhilip M Bath
Nov 10, 2020·Stroke; a Journal of Cerebral Circulation·Sajith C SenadeeraTeddy Y Wu
Sep 4, 2020·Acta Neurologica Scandinavica·Prithvi Santana BaskarSonu Bhaskar
Feb 17, 2021·Stroke; a Journal of Cerebral Circulation·Cathy S ZhongTeddy Y Wu
Jun 9, 2021·Acta Neurologica Scandinavica·Prithvi Santana BaskarSonu Menachem Maimonides Bhaskar
Jul 20, 2021·Rinshō shinkeigaku = Clinical neurology·Masatoshi KogaKazunori Toyoda

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Benjamin Y Q TanLeonard L L Yeo
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Bing Yu ChenAlexandre Y Poppe
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
A M Iglesias MohedanoA Gil Núñez
International Journal of Stroke : Official Journal of the International Stroke Society
Noreen KamalMichael D Hill
© 2022 Meta ULC. All rights reserved