Hemadsorption and virulence are separable properties of Mycoplasma pneumoniae.

Infection and Immunity
D K LeithJ B Baseman

Abstract

A selective enrichment technique was used to isolate a hemadsorption-positive revertant of a hemadsorption-negative mutant strain of Mycoplasma pneumoniae. This hemadsorption-positive revertant was shown to have simultaneously regained both the ability to attach to neuraminidase-sensitive receptors on the tracheal ring respiratory epithelium in vitro and the ability to synthesize three virulent-strain-specific proteins which were not synthesized by the hemadsorption-negative mutant. Despite the persistence of the revertant in hamster lung tissue for 9 to 12 weeks postinfection, no cytopathology was observed. Intranasal inoculation of the revertant provided limited protection against a challenge dose of virulent M. pneumoniae.

References

Mar 1, 1976·Infection and Immunity·D A PowellJ B Baseman
Mar 1, 1979·Infection and Immunity·E J HansenJ B Baseman
Feb 10, 1976·Biochemistry·G F Ames, K Nikaido
May 1, 1977·The Journal of Experimental Medicine·P C HuJ B Baseman
Dec 1, 1971·Infection and Immunity·W A Clyde
Nov 1, 1969·Journal of Bacteriology·R P LipmanF W Denny
Dec 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·A M CollierF W Denny
Sep 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·R P Lipman, W A Clyde
Jan 1, 1981·Infection and Immunity·S Upchurch, M G Gabridge
Apr 1, 1981·Infection and Immunity·E J HansenJ B Baseman
Jan 1, 1981·Advances in Experimental Medicine and Biology·E J HansenJ B Baseman
Sep 1, 1982·Journal of Bacteriology·J B BasemanD K Leith
Jun 1, 1965·The Journal of Experimental Medicine·A S DAJANIF W DENNY
Jun 1, 1970·Infection and Immunity·G W Fernald, W A Clyde

❮ Previous
Next ❯

Citations

Jun 6, 2003·Molecular Microbiology·René A AlvarezJoel B Baseman
Feb 1, 1983·Infection and Immunity·D C KrauseJ B Baseman
Aug 1, 1988·Infection and Immunity·D C Krause, Y Y Chen
Jan 1, 1984·Annales de microbiologie·I KahaneA Reisch-Saada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
C T StadtländerG H Cassell
© 2021 Meta ULC. All rights reserved