Hemadsorption immunosorbent technique for determination of mumps immunoglobulin M antibody.

Journal of Clinical Microbiology
J van der LogtJ van der Veen


We used hemadsorption immunosorbent technique (HIT) to detect mumps immunoglobulin M (IgM) antibody. IgM from human sera was adsorbed into anti-human IgM-coated wells in plates, and mumps-specific IgM was detected by adding mumps virus hemagglutinin and guinea pig erythrocytes consecutively. Specific IgM-positive sera showed hemadsorption, whereas negative sera showed hemagglutination. All 81 patients with current mumps infections tested showed mumps-specific IgM antibody, with titers ranging from 160 to 327,680. In most cases IgM antibody was already present on day 1 or 2 after the onset of illness. IgM antibody persisted for 6 to 10 weeks. Of 57 patients with acute respiratory illnesses caused by parainfluenza virus, 5 showed cross-reactions in the hemadsorption immunosorbent technique assay for mumps IgM. The hemadsorption immunosorbent technique assay is specific for the IgM class of antibody and avoids false-positive results due to rheumatoid factor. This test is an efficient and sensitive method for rapid and early diagnosis of mumps infections.


Aug 1, 1979·The Journal of Infectious Diseases·B FlehmigH J Gerth
Jan 1, 1979·Journal of Clinical Pathology·F KleinJ M Singer
Jan 1, 1974·Scandinavian Journal of Infectious Diseases·B Bjorvatn
Mar 1, 1973·Infection and Immunity·H DaughartyH L Casey
Aug 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E B BuynakM R Hilleman
Sep 1, 1980·The Journal of General Virology·H SchmitzB Flehmig
Mar 1, 1981·Journal of Clinical Microbiology·J T van der LogtJ van der Veen
Dec 1, 1980·The Journal of Hygiene·J H WagenvoortK C Winkler
Apr 1, 1981·The Journal of Hygiene·P P MortimerU Schilt

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Jan 1, 1982·Journal of Medical Virology·J T van der LogtJ van der Veen
Feb 28, 2020·Clinical Microbiology Reviews·Eugene LamJane R Zucker
Aug 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·G GlikmannC H Mordhorst
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·F V PlappJ M Rachel

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