Hemagglutinin-Mediated Membrane Fusion: A Biophysical Perspective

Annual Review of Biophysics
Sander BoonstraAntoine M van Oijen

Abstract

Influenza hemagglutinin (HA) is a viral membrane protein responsible for the initial steps of the entry of influenza virus into the host cell. It mediates binding of the virus particle to the host-cell membrane and catalyzes fusion of the viral membrane with that of the host. HA is therefore a major target in the development of antiviral strategies. The fusion of two membranes involves high activation barriers and proceeds through several intermediate states. Here, we provide a biophysical description of the membrane fusion process, relating its kinetic and thermodynamic properties to the large conformational changes taking place in HA and placing these in the context of multiple HA proteins working together to mediate fusion. Furthermore, we highlight the role of novel single-particle experiments and computational approaches in understanding the fusion process and their complementarity with other biophysical approaches.

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Citations

Sep 9, 2020·Journal of Leukocyte Biology·Mitchell KlompM Nadeem Khan
May 13, 2018·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·R Brian Dyer, Micah W Eller
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Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Feb 12, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei LuoFujiang Guo
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Sep 1, 2021·Current Opinion in Virology·Peter Eugene JonesJodi A Hadden-Perilla
Oct 26, 2021·Angewandte Chemie·Joon Ho ParkLiangfang Zhang

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Methods Mentioned

BETA
confocal microscopy
optical
fluorescence microscopy
fluorescence

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