Hemagglutinin of influenza virus partitions into the nonraft domain of model membranes.

Biophysical Journal
Jörg NikolausAndreas Herrmann

Abstract

The HA of influenza virus is a paradigm for a transmembrane protein thought to be associated with membrane-rafts, liquid-ordered like nanodomains of the plasma membrane enriched in cholesterol, glycosphingolipids, and saturated phospholipids. Due to their submicron size in cells, rafts can not be visualized directly and raft-association of HA was hitherto analyzed by indirect methods. In this study, we have used GUVs and GPMVs, showing liquid disordered and liquid ordered domains, to directly visualize partition of HA by fluorescence microscopy. We show that HA is exclusively (GUVs) or predominantly (GPMVs) present in the liquid disordered domain, regardless of whether authentic HA or domains containing its raft targeting signals were reconstituted into model membranes. The preferential partition of HA into ld domains and the difference between lo partition in GUV and GPMV are discussed with respect to differences in packaging of lipids in membranes of model systems and living cells suggesting that physical properties of lipid domains in biological membranes are tightly regulated by protein-lipid interactions.

References

Feb 25, 1992·Biochemistry·T J McIntoshC H Huang
Oct 1, 1986·The Journal of Cell Biology·C S CopelandA Helenius
Aug 1, 1984·Biophysical Journal·O G Mouritsen, M Bloom
Jan 16, 1999·The Journal of Biological Chemistry·P ScheiffeleK Simons
Apr 20, 2000·The Journal of Biological Chemistry·D A Brown, E London
Nov 5, 2002·Biophysical Journal·H Heerklotz
Mar 1, 2003·Biophysical Journal·J A LundbaekC Nielsen
Mar 22, 2003·Biochimica Et Biophysica Acta·John R Silvius
Oct 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Makoto TakedaRobert A Lamb
Nov 19, 2003·Cell·Sean Munro
Nov 25, 2003·FEBS Letters·J Antoinette Killian
Mar 3, 2004·Nature Biotechnology·Megan A RizzoDavid W Piston
Jul 9, 2004·Biophysical Journal·Philippe GirardPatricia Bassereau
Mar 9, 2005·The Journal of Biological Chemistry·Hidehiko ShogomoriDeborah A Brown
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·A T HammondG W Feigenson
Feb 14, 2006·Biochimica Et Biophysica Acta·Paulo F F AlmeidaAnne Hinderliter
Apr 21, 2006·Nature Reviews. Molecular Cell Biology·John F Hancock
Jan 3, 2007·Nature Cell Biology·Ken JacobsonRichard G W Anderson
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tobias BaumgartWatt W Webb
Mar 21, 2007·The Journal of Biological Chemistry·Andreas PapadopulosAndreas Herrmann
Jun 26, 2007·Biochimica Et Biophysica Acta·Tobias BaumgartGerald W Feigenson
Oct 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Samuel T HessJoshua Zimmerberg
Mar 4, 2008·Nature Chemical Biology·Ivan V PolozovJoshua Zimmerberg
Jul 22, 2008·Nature Chemical Biology·Rémi LasserreHai-Tao He
Oct 22, 2008·Biochimica Et Biophysica Acta·Aurelia R Honerkamp-SmithSarah L Keller

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Citations

Apr 26, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Maria O OgunyankinMarjorie L Longo
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lars V SchäferSiewert J Marrink
Dec 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ilya LeventalKai Simons
Apr 18, 2013·PLoS Computational Biology·Daniel L PartonMark S P Sansom
Aug 5, 2015·Chemistry and Physics of Lipids·Joseph Helmuth Lorent, Ilya Levental
Nov 6, 2012·Cellular Microbiology·Heiko KellerPetra Schwille
Sep 3, 2011·Biochimica Et Biophysica Acta·Jan DomańskiLars V Schäfer
Mar 28, 2012·Biochimica Et Biophysica Acta·Erdinc SezginPetra Schwille
Aug 23, 2011·Biochimica Et Biophysica Acta·Jörg NikolausPeter Müller
Jul 27, 2012·Molecular Membrane Biology·Erdinc Sezgin, Petra Schwille
Dec 30, 2014·Current Opinion in Cell Biology·Romain Volmer, David Ron
Feb 2, 2011·Biophysical Journal·Sai LiIwan A T Schaap
Feb 28, 2016·FEBS Letters·Petr Chlanda, Joshua Zimmerberg
Feb 9, 2012·Advances in Virology·Michael Veit, Bastian Thaa
Feb 16, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Eric S FriedM Lane Gilchrist
Mar 14, 2018·Infection and Immunity·Krishnan RaghunathanAnne K Kenworthy
Apr 30, 2020·Biotechnology Journal·Danila BoytsovPeter Pohl
Aug 22, 2020·Chemical Communications : Chem Comm·Guilherme B BerselliTia E Keyes
Apr 18, 2015·Chembiochem : a European Journal of Chemical Biology·Daniel LausterAndreas Herrmann
Jan 26, 2017·Frontiers in Cell and Developmental Biology·Mary L Kraft
Jan 3, 2014·Angewandte Chemie·Holger A ScheidtDaniel Huster
Jan 8, 2013·Journal of the American Chemical Society·Friedrich RoderJacob Piehler
May 7, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Maria O OgunyankinMarjorie L Longo
Aug 20, 2020·The Journal of Physical Chemistry. B·Deniz Yurtsever, Joseph Helmuth Lorent
Jun 15, 2019·ACS Nano·Guillermo Moreno-PescadorPoul Martin Bendix

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