Hemangioblastic foci in human first trimester placenta: Distribution and gestational profile

Placenta
John D AplinCarolyn J P Jones

Abstract

The human placenta is a site of both hematopoiesis and vasculogenesis. There are reports of hemangioblastic foci (HAF) in the first trimester placenta, but little published information about their spatiotemporal incidence. We have used semi-thin sections and whole mount staining techniques on archival early pregnancy hysterectomy material as well as freshly-collected termination tissue. We report a description of the distribution of HAF, their gestational profile, and some characteristics of the constituent cells. We show crypt-shaped HAF are present in villi at different levels from 4 to 11 weeks and in the chorionic plate from 4 to 9 weeks. In the villous placenta, the foci often approach closely at one end to the trophoblast basement membrane. Morphologically they show remarkable similarity to those found in the yolk sac at similar stages. In some crypts, all cells are CD34+, but CD34 and nestin progressively segregate into the endothelial lineage. Brachyury is present in less differentiated cells. The erythroid lineage is dominant, as shown by the widespread expression of CD235a/glycophorin and characteristic erythroid morphologies, indicating various degrees of differentiation. However, CD41 is also present in non-endothel...Continue Reading

References

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Citations

May 1, 2018·Frontiers in Physiology·Graham J Burton, Eric Jauniaux
Jul 1, 2020·Nature Reviews. Endocrinology·John D AplinMelissa Westwood
May 3, 2019·Cellular and Molecular Life Sciences : CMLS·Martin KnöflerJoanna James
Sep 27, 2018·Human Reproduction Update·Anna L BossJoanna L James

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