Hematite (Fe2O3) acts by oxydative stress and potentiates benzo[a]pyrene genotoxicity

Mutation Research
Sébastien GarryDaniel Marzin

Abstract

Since epidemiological studies have implicated the co-exposition of iron oxides and polycyclic aromatic hydrocarbons as potential etiological factors involved in the excess of mortality from lung cancer in miners, experimental studies have been performed to investigate the role of iron on benzo[a]pyrene (B[a]P)-induced lung pathogenesis. We demonstrated previously that in vivo damage was higher when B[a]P was coated onto hematite than when B[a]P was administered alone. In order to determine the role of (i) different cell types and (ii) adsorption of hematite in this potentiation, in vitro studies were developed. The Comet assay was first used to measure DNA damage in four isolated cell types from Sprague-Dawley rats at 1, 2, 4, 8 and 24h after in vitro treatment with hematite (Fe2O3) or B[a]P or B[a]P coated onto hematite. For the two treatments with B[a]P, no damage was observed in alveolar macrophages, but significant increases in damage were seen in lymphocytes, hepatocytes and lung cells (where the effects of B[a]P coated onto hematite were stronger than those of B[a]P alone). In a second part of the study, the Comet assay was conducted with lung cells to measure the in vitro effect of (i) the coating and (ii) the role of th...Continue Reading

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Citations

Dec 18, 2014·Fertility and Sterility·Shaoquan ZhanJunjiu Huang
Oct 20, 2009·Nutrition and Cancer·Daniel PráMichael Fenech
Jan 1, 2013·Cancer Nanotechnology·Chandrababu RejeethSoundarapandian Kannan

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