Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity

Scientific Reports
Yanhong LiChuan Qin

Abstract

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis in children. Animal models of HSP are needed to better understand the mechanism of HSP. Here, we investigated hematologic and immunologic profiles in HSP rat and rabbit models. Models were established with ovalbumin (OVA) based on type III hypersensitivity. During the acute phase, the models exhibited varying degrees of cutaneous purpura, joint inflammatory response, gastrointestinal bleeding, glomerular capsule protein exudation, vascular dilatation, and increased IgA expression and immune complex deposition. Twenty four hours after antigen challenge, compared with the controls, the models showed a significantly increased white blood cell count and granulocytes count and percentage, decreased number and percentage of lymphocytes, no change in platelet concentration, significantly increased serum IL-4 and TNF-α levels, and decreased CD4(+) T cell, CD4/CD8 ratio, and C3 and C4 levels. Compared with the hematologic and immunologic profiles in pediatric HSP patients, the rat and rabbit HSP models can mimic pediatric HSP characteristics. Our studies provide two useful animal models for further investigations of the pathogenesis, diagnosis, drug screening and treatment o...Continue Reading

References

Sep 1, 1977·Acta paediatrica Scandinavica·S SimiläM Lanning
May 1, 1992·Journal of Clinical Immunology·N KondoT Orii
Aug 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G C SmithT J Beattie
Jan 1, 1997·Scandinavian Journal of Rheumatology·N BesbasA M Elnahas
Jan 23, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M K NamgoongJ S Kim
Jan 16, 1999·Gastroenterology Clinics of North America·M BaileyJ C Reynolds
Jun 26, 2001·European Journal of Pediatrics·I IslekC Dilber
Jun 28, 2002·Cleveland Clinic Journal of Medicine·Frank T Saulsbury
Mar 26, 2003·International Journal of Dermatology·Fernando C Fervenza
May 12, 2004·Current Rheumatology Reports·Abraham Gedalia
Jan 15, 2008·Autoimmunity Reviews·Yao-Hsu YangBor-Luen Chiang
Aug 16, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Andrew FretzayasPolyxeni Nicolaidou
Jun 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Keith K LauRobert J Wyatt
May 1, 2007·Frontiers of Medicine in China·Shuijun ZhangShi Chen

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BETA
enzyme-linked
flow cytometry
ELISA
flow

Software Mentioned

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SPSS
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