Hematologic changes in nutritional lead deficiency

Annals of Nutrition & Metabolism
A M Reichlmayr-Lais, M Kirchgessner

Abstract

In the present experiments hematological changes could be induced in growing rats by alimentary lead deficiency. The lead-depleted mothers of different generations had already shown a trend to lower values of hematocrit and mean corpuscular volume in comparison with control mothers. In young male rats of the F1-generation from lead-depleted mothers hematocrit was reduced by about 22%, hemoglobin by about 25%, the mean corpuscular volume by about 23%, and the mean corpuscular hemoglobin by about 28% as determined 3 days after weaning in comparison with control rats. Depletion of female rats till the 38th day of life intensified the hematological changes: hematocrit values were reduced by about 14%, hemoglobin by about 32%, the mean corpuscular volume by about 29%, mean corpuscular hemoglobin by about 37%, and the mean corpuscular hemoglobin concentration by about 12%. In the F2-generation rats of the depletion group always showed changed hematological values in comparison with control animals. Hematological changes normalized by repletion starting from the day of birth (crossing-over experiment) or the day of weaning (depletion-repletion experiment). In the crossing-over experiment, in which one half of the littermates of the le...Continue Reading

Citations

Jul 1, 1988·Biological Trace Element Research·E O Uthus, F H Nielsen
Sep 1, 1996·Zeitschrift für Ernährungswissenschaft·J EberleM Kirchgessner
Sep 1, 1986·Zeitschrift für Ernährungswissenschaft·A M Reichlmayr-Lais, M Kirchgessner
Dec 1, 1996·Zeitschrift für Ernährungswissenschaft·J EberleM Kirchgessner

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