Hematologic Complications of Immune Checkpoint Inhibitors

The Oncologist
Elizabeth J DavisDouglas B Johnson

Abstract

Immune checkpoint inhibitors have improved outcomes for patients with numerous hematological and solid cancers. Hematologic toxicities have been described, but the spectrum, timing, and clinical presentation of these complications are not well understood. We used the World Health Organization's pharmacovigilance database of individual-case-safety-reports (ICSRs) of adverse drug reactions, VigiBase, to identify cases of hematologic toxicities complicating immune checkpoint inhibitor therapy. We identified 168 ICSRs of immune thrombocytopenic purpura (ITP), hemolytic anemia (HA), hemophagocytic lymphohistiocytosis, aplastic anemia, and pure red cell aplasia in 164 ICSRs. ITP (n = 68) and HA (n = 57) were the most common of these toxicities and occurred concomitantly in four patients. These events occurred early on treatment (median 40 days) and were associated with fatal outcome in 12% of cases. Ipilimumab-based therapy (monotherapy or combination with anti-programmed death-1 [PD-1]) was associated with earlier onset (median 23 vs. 47.5 days, p = .006) than anti-PD-1/programmed death ligand-1 monotherapy. Reporting of hematologic toxicities has increased over the past 2 years (98 cases between January 2017 and March 2018 vs. 70 c...Continue Reading

Associated Clinical Trials

References

Jan 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kohei HosokawaNeal S Young
Jan 23, 2016·Melanoma Research·Benjamin Y KongMatteo S Carlino
Mar 18, 2016·The New England Journal of Medicine·Ranjit NairSuresh G Nair
Dec 7, 2016·Case Reports in Oncology·Amruth R PallaDonald Doll
Feb 28, 2017·Journal for Immunotherapy of Cancer·Eileen ShiuanDouglas Johnson
Apr 4, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nausicaa MalissenJean-Jacques Grob
Apr 4, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D ShahH Saeed
Feb 24, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Imke SatzgerRalf Gutzmer

❮ Previous
Next ❯

Citations

Jan 17, 2020·CA: a Cancer Journal for Clinicians·Lucy Boyce Kennedy, April K S Salama
Jul 7, 2019·Journal for Immunotherapy of Cancer·Abdul Rafeh NaqashPaul R Walker
Nov 7, 2019·The Oncologist·Sara R SchoenfeldKerry L Reynolds
Mar 5, 2020·Expert Opinion on Drug Safety·José Mª Mazarico GallegoLuis Paz-Ares
Mar 15, 2020·Journal for Immunotherapy of Cancer·Daniel J OlsonThomas F Gajewski
May 19, 2020·The Western Journal of Emergency Medicine·Brit LongAlex Koyfman
May 10, 2020·Nature Reviews. Disease Primers·Manuel Ramos-CasalsMaria E Suárez-Almazor
Dec 10, 2019·Rheumatology·Noha Abdel-Wahab, Maria E Suarez-Almazor
Apr 3, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ali YılmazSalim Başol Tekin
Oct 6, 2020·JCO Precision Oncology·Peter G MillerBenjamin L Ebert
Sep 14, 2019·Seminars in Oncology Nursing·Marianne Davies
Sep 26, 2020·Cold Spring Harbor Molecular Case Studies·Tammarah SklarzDaria Babushok
Aug 20, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tariq KewanHamed Daw
Mar 12, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rafaela KramerLucie Heinzerling
Mar 15, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pascaline Boudou-RouquetteLaurent Chouchana
Jul 13, 2021·Journal of Clinical Immunology·Daisuke ToyamaShohei Yamamoto
Jul 5, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yuan YuanJoanne Mortimer
Aug 28, 2021·The American Journal of Emergency Medicine·Michael J YooMichael Gottlieb
Jun 18, 2021·American Journal of Hematology·Antoine N SalibaAref Al-Kali
Nov 2, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan J SchneiderKathryn Bollin
Sep 2, 2021·Journal of Immunotherapy·Nathaniel R WilsonCristhiam M Rojas-Hernandez
Dec 11, 2021·Hematology·Kelly Walkovich, James A Connelly
Jan 28, 2022·Nature Reviews. Clinical Oncology·Douglas B JohnsonJustin M Balko

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
dissection
biopsy

Software Mentioned

MEDdra

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
A Urabe
[Rinshō ketsueki] The Japanese journal of clinical hematology
Masanao Teramura
[Rinshō ketsueki] The Japanese journal of clinical hematology
Ken-ichi Sawada
© 2022 Meta ULC. All rights reserved