Hematologic effects of cis-platinum-bleomycin therapy

Oncology
T NajarianW Ki Hong

Abstract

A prospective study of the hematologic findings in 19 patients receiving cis-platinum (C-P) bleomycin (B) for squamous cell carcinoma of the head and neck was performed. CP 3 mg/kg was given on day 1, B 15 mg/m2 on day 3 and then by continuous infusison from day 3 to 10. Hematocrits declined in all patients from a mean of 41.6 +/- 3.9 to 36.6 +/- 4.9 (p less than 0.001) with the nadir seen by 10 days, reticulocyte count was unchanged. In 1 patient marked hemolysis occurred over 10-day period associated with the appearance of irregular spherocytes on smear, a situation similar to the index case which initiated this study. 5 other patients had spherocytes. A significant lymphopenia in the absence of neutropenia and thrombocytopenia was also observed.

Citations

Sep 1, 1983·Cancer Treatment Reviews·D C Doll, R B Weiss
Sep 1, 1983·Scandinavian Journal of Haematology·M DawsonR D Barr
Jan 23, 2021·Critical Reviews in Oncology/hematology·Michael I Koukourakis, Alexandra Giatromanolaki

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